Product Name
Elastin (ELN), Blocking Peptide
Full Product Name
Elastin Blocking Peptide
Product Synonym Names
Elastin; Tropoelastin
Product Gene Name
ELN blocking peptide
[Similar Products]
Elastin peptide (MBS823599) is used for blocking the activity of Elastin antibody (MBS821275)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P15502
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of ELN blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ELN blocking peptide
The peptide is used to block Anti-Elastin Antibody reactivity.
Applications Tested/Suitable for ELN blocking peptide
Blocking (BL)
Application Notes for ELN blocking peptide
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
NCBI/Uniprot data below describe general gene information for ELN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000492.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000501.3
[Other Products]
UniProt Primary Accession #
P15502
[Other Products]
UniProt Secondary Accession #
O15336; O15337; Q14233; Q14234; Q14235; Q14238; Q6P0L4; Q6ZWJ6; Q75MU5; Q7Z316; B3KTS6[Other Products]
UniProt Related Accession #
P15502[Other Products]
Molecular Weight
60,980 Da
NCBI Official Full Name
elastin isoform a
NCBI Official Synonym Full Names
elastin
NCBI Official Symbol
ELN??[Similar Products]
NCBI Official Synonym Symbols
WS; WBS; SVAS
??[Similar Products]
NCBI Protein Information
elastin; tropoelastin
UniProt Protein Name
Elastin
UniProt Synonym Protein Names
Tropoelastin
UniProt Gene Name
ELN??[Similar Products]
UniProt Entry Name
ELN_HUMAN
NCBI Summary for ELN
This gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ELN
elastin: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Defects in ELN are the cause of cutis laxa, autosomal dominant, type 1 (ADCL1). A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Defects in ELN are the cause of supravalvular aortic stenosis (SVAS). SVAS is a congenital narrowing of the ascending aorta which can occur sporadically, as an autosomal dominant condition, or as one component of Williams-Beuren syndrome. ELN is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of ELN may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. Belongs to the elastin family. 13 isoforms of the human protein are produced by alternative splicing.
Protein type: Extracellular matrix; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: proteinaceous extracellular matrix; extracellular region
Molecular Function: protein binding; extracellular matrix structural constituent
Biological Process: cell proliferation; extracellular matrix disassembly; organ morphogenesis; extracellular matrix organization and biogenesis; blood circulation; respiratory gaseous exchange
Disease: Cutis Laxa, Autosomal Dominant 1; Williams-beuren Syndrome; Supravalvular Aortic Stenosis
Research Articles on ELN
1. AAA-SMCs have a unique gene expression profile and a proelastolytic phenotype that is augmented by macrophages.
Precautions
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Disclaimer
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