Anti -Myotubularin Related Protein 2 (MTMR2)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 11; NC_000011.9 (95566044..95657371, complement). Location: 11q22

Polyclonal

IgY

Chicken

Recognizes human Myotubularin Related Protein 2.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Glycerol free.

May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-MTMR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The gene encoding this protein is a member of the myotubularin family and encodes a putative tyrosine phosphatase. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Multiple alternatively spliced transcript variants have been found, but the biological validity of some variants has not been determined.

Antibodies; Abs to Proteins

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:2000

73,381 Da[Similar Products]

myotubularin related protein 2

myotubularin-related protein 2; OTTHUMP00000204445; OTTHUMP00000204446; OTTHUMP00000204447; OTTHUMP00000204448

Myotubularin-related protein 2

KIAA1073??[Similar Products]

MTMR2_HUMAN

This gene is a member of the myotubularin family. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

MTMR2: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. Homooligomer and heterooligomer. Interacts with SBF1 and SBF2. interaction with SBF1 increases phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Protein type: EC 3.1.3.64; Phosphatase, lipid; EC 3.1.3.95; Protein phosphatase, tyrosine (non-receptor); Cofactor and Vitamin Metabolism - riboflavin; Cofactor and Vitamin Metabolism - thiamine; Carbohydrate Metabolism - fructose and mannose; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q22

Cellular Component: synaptic vesicle; early endosome membrane; axon; dendrite; cytoplasm; vacuolar membrane; dendritic spine; nucleus; cytosol

Molecular Function: protein binding; phosphatidylinositol-3-phosphatase activity; protein homodimerization activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: myelin formation; negative regulation of myelination; phospholipid metabolic process; negative regulation of endocytosis; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; neuron development; protein amino acid dephosphorylation; protein tetramerization; negative regulation of receptor internalization

Disease: Charcot-marie-tooth Disease, Type 4b1

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