For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Purified by antigen-affinity chromatography.

Supplied in 0.1M Tris-buffered saline with 20% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.

Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.

Small volumes of anti-MTMR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene is a member of the myotubularin family. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

Total protein Ab

Western Blot (WB), Immunohistochemistry (IHC)

Western blotting: 1:500-1:3000
Immunohistochemistry: 1:100-1:250

Sample (30 ug of whole cell lysate) A: Hep G2 7.5% SDS PAGE Primary antibody diluted at 1: 1000

Immunohistochemical analysis of paraffin-embedded CL1-0 xenograft, using Myotubularin related protein 2 antibody at 1: 100 dilution.

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MTMR2_HUMAN

This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

MTMR2: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. Homooligomer and heterooligomer. Interacts with SBF1 and SBF2. interaction with SBF1 increases phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Protein type: Phosphatase, lipid; EC 3.1.3.64; Carbohydrate Metabolism - fructose and mannose; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.95; Cofactor and Vitamin Metabolism - riboflavin; Cofactor and Vitamin Metabolism - thiamine

Chromosomal Location of Human Ortholog: 11q22

Cellular Component: synaptic vesicle; early endosome membrane; axon; vacuolar membrane; cytoplasm; dendrite; dendritic spine; nucleus; cytosol

Molecular Function: phosphatidylinositol-3-phosphatase activity; protein binding; protein homodimerization activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: myelin formation; negative regulation of myelination; phospholipid metabolic process; negative regulation of endocytosis; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; neuron development; phosphoinositide dephosphorylation; protein amino acid dephosphorylation; protein tetramerization; negative regulation of receptor internalization

Disease: Charcot-marie-tooth Disease, Type 4b1

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