Adra 2c; ADRA2C; ADRA2L2; ADRA2RL2; ADRARL2; Adrenergic alpha 2C receptor; Adrenoceptor alpha 2C; Alpha 2C adrenergic receptor; Alpha 2C adrenergic receptor subtype C4; Alpha 2C adrenoceptor; Alpha 2C adrenoreceptor; Alpha 2CAR; Alpha-2-adrenergic receptor, renal type; alpha2 AR C4; alpha2 C4; alpha2C; ALPHA2CAR; alpha2cii-adrenergic receptor; Subtype alpha2 C4

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Adrenergic Receptor alpha-2C antibody detects endogenous levels of total Adrenergic Receptor alpha-2C

The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.

Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1mg/ml (lot specific)

Store at -20 degree C. Stable for 12 months from date of receipt.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Small volumes of anti-ADRA2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.

Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)

WB: 1:500-1:1000
IF/ICC: 1:100-1:500

MBS9604571 staining HepG2 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.

Western blot analysis of Adrenergic Receptor alpha-2C expression in mouse brain lysate

Western blot analysis of extracts from HepG2 cells, using Adrenergic Receptor alpha-2C antibody.The lane on the left is treated with the antigen-specific peptide.

Observed: 70 kD
Predicted: 50 kDa

adrenoceptor alpha 2C

alpha-2C adrenergic receptor

Alpha-2C adrenergic receptor

ADRA2L2; ADRA2RL2; Alpha-2C adrenoceptor; Alpha-2CAR??[Similar Products]

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

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