myotubularin related protein 2; MTMR2; CMT4B; CMT4B1; KIAA1073

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purified

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-MTMR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Western Blot (WB)

65,959 Da[Similar Products]

myotubularin related protein 2

myotubularin-related protein 2

Myotubularin-related protein 2

MTMR2_HUMAN

This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

MTMR2: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. Homooligomer and heterooligomer. Interacts with SBF1 and SBF2. interaction with SBF1 increases phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.64; Cofactor and Vitamin Metabolism - thiamine; EC 3.1.3.95; Protein phosphatase, tyrosine (non-receptor); Cofactor and Vitamin Metabolism - riboflavin; Carbohydrate Metabolism - fructose and mannose; Phosphatase, lipid

Chromosomal Location of Human Ortholog: 11q22

Cellular Component: synaptic vesicle; early endosome membrane; axon; vacuolar membrane; dendrite; cytoplasm; dendritic spine; nucleus; cytosol

Molecular Function: phosphatidylinositol-3-phosphatase activity; protein binding; protein homodimerization activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: myelin formation; negative regulation of myelination; inositol phosphate dephosphorylation; phospholipid metabolic process; negative regulation of endocytosis; phosphatidylinositol biosynthetic process; neuron development; phosphoinositide dephosphorylation; protein amino acid dephosphorylation; protein tetramerization; negative regulation of receptor internalization

Disease: Charcot-marie-tooth Disease, Type 4b1

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.