Full Product Name
ANXA8 (Annexin A8, Annexin-8, Annexin VIII, Vascular Anticoagulant-beta, VAC-beta, ANX8)
Product Synonym Names
Anti -ANXA8 (Annexin A8, Annexin-8, Annexin VIII, Vascular Anticoagulant-beta, VAC-beta, ANX8)
Product Gene Name
anti-ANXA8 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 10; NC_000010.10 (48255204..48271369). Location: 10q11.22
3D Structure
ModBase 3D Structure for P13928
Specificity
Recognizes human ANXA8.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
Immunogen
Synthetic peptide corresponding to SSLEEDIQADTSGY in human ANXA8.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ANXA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ANXA8 antibody
Antibodies; Abs to Annexin
Applications Tested/Suitable for anti-ANXA8 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ANXA8 antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1.5-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
NCBI/Uniprot data below describe general gene information for ANXA8. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001258631.1
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NCBI GenBank Nucleotide #
NM_001271702.1
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UniProt Primary Accession #
P13928
[Other Products]
UniProt Secondary Accession #
Q5VTM4; Q6GMY3; Q9BT34; A6NLM1[Other Products]
UniProt Related Accession #
P13928[Other Products]
Molecular Weight
36,881 Da[Similar Products]
NCBI Official Full Name
annexin A8 isoform 1
NCBI Official Synonym Full Names
annexin A8
NCBI Official Symbol
ANXA8??[Similar Products]
NCBI Official Synonym Symbols
ANX8
??[Similar Products]
NCBI Protein Information
annexin A8; VAC-beta; annexin-8; annexin VIII; vascular anticoagulant-beta
UniProt Protein Name
Annexin A8
UniProt Synonym Protein Names
Annexin VIII; Annexin-8; Vascular anticoagulant-beta
UniProt Gene Name
ANXA8??[Similar Products]
UniProt Synonym Gene Names
ANX8; VAC-beta??[Similar Products]
UniProt Entry Name
ANXA8_HUMAN
NCBI Summary for ANXA8
This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]
UniProt Comments for ANXA8
ANXA8: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Belongs to the annexin family.
Chromosomal Location of Human Ortholog: 10q11.22
Cellular Component: late endosome membrane; plasma membrane; cytosol
Molecular Function: actin filament binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; calcium-dependent phospholipid binding; calcium ion binding; phosphatidylinositol-3,4-bisphosphate binding
Biological Process: endosome organization and biogenesis; blood coagulation; endosome transport
Research Articles on ANXA8
1. Define a distinct bone-dependent genetic program associated with terminal osteoclast differentiation and identified Anxa8 as a gene strongly induced late in osteoclast differentiation, regulating formation of the cell's characteristic actin ring.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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