Anti -ANXA8 (Annexin A8, Annexin-8, Annexin VIII, Vascular Anticoagulant-beta, VAC-beta, ANX8)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 10; NC_000010.10 (48255204..48271369). Location: 10q11.22

Polyclonal

IgG

Rabbit

Recognizes human Annexin VIII at ~28-30kD and ~36kD.

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-ANXA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The annexin family of calcium-binding proteins is composed of at least ten mammalian genes. It is characterized by a conserved core domain which binds to phospholipids in a Ca2+-dependent manner. Annexin family members have been implicated as regulators of diverse processes as ion flux, endocytosis and exocytosis, and cellular adhesion. Annexin VIII is preferentially expressed in acute promyelocytic leukemia (APL) cells which may relate its role in hematopoietic cell differentiation.

Antibodies; Abs to Annexin

Western Blot (WB)

Suitable for use in Western Blot.
Dilution: Western Blot: 0.5-4ug/ml

36,881 Da[Similar Products]

annexin A8

annexin A8; VAC-beta; annexin-8; annexin VIII; vascular anticoagulant-beta

Annexin A8

ANX8; VAC-beta??[Similar Products]

ANXA8_HUMAN

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]

Function: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Domain: A pair of annexin repeats may form one for calcium and phospholipid.

Sequence similarities: Belongs to the annexin family.Contains 4 annexin repeats.

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