Product Name
(Rhesus macaque) Plasminogen (PLG), Recombinant Protein
Popular Item
Full Product Name
Recombinant Macaca mulatta (Rhesus macaque) Plasminogen (PLG)
Product Synonym Names
Recombinant (Rhesus macaque) Plasminogen (PLG); Plasminogen EC= 3.4.21.7 Cleaved into the following 4 chains: 1. Plasmin heavy chain A 2. Activation peptide 3. Plasmin heavy chain A, short form 4. Plasmin light chain B
Product Gene Name
PLG recombinant protein
[Similar Products]
Product Synonym Gene Name
PLG[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
581-810
Sequence
VVGGCVAYPH SWPWQISLRT RLGMHFCGGT LISPEWVLTA AHCLEKSSRP SFYKVILGAH REVHLEPHVQ EIEVSKMFSE PARADIALLK LSSPAIITDK VIPACLPSPN YVVADRTECF ITGWGETQGT YGAGLLKEAR LPVIENKVCN RYEFLNGTVK TTELCAGHLA GGTDSCQGDS GGPLVCFEKD KYILQGVTSW GLGCARPNKP GVYVRVSRFV TWIEGVMRNN
Chromosome Location
Chromosome: 4; NC_007861.1 (157592455..157641186). Location: chromosome: 4
3D Structure
ModBase 3D Structure for P12545
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Macaca mulatta (Rhesus macaque)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PLG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PLG. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001036540.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001043075.1
[Other Products]
UniProt Primary Accession #
P12545
[Other Products]
UniProt Related Accession #
P12545[Other Products]
Molecular Weight
90,255 Da[Similar Products]
NCBI Official Full Name
plasminogen
NCBI Official Symbol
PLG??[Similar Products]
NCBI Protein Information
plasminogen
UniProt Protein Name
Plasminogen
Protein Family
Plasminogen
UniProt Gene Name
PLG??[Similar Products]
UniProt Entry Name
PLMN_MACMU
UniProt Comments for PLG
Function: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells
By similarity.
Catalytic activity: Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
Enzyme regulation: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase.
Subunit structure: Interacts with CSPG4 and AMOT. Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation
By similarity.
Subcellular location: Secreted
By similarity. Note: Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface
By similarity.
Domain: Kringle domains mediate interaction with CSPG4
By similarity.
Post-translational modification: In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide
By similarity.
Miscellaneous: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.In the presence of the inhibitor, the activation involves only cleavage after Arg-580, resulting in 2 chains held together by 2 disulfide bonds. Without the inhibitor, the activation involves also removal of the activation peptide.
Sequence similarities: Belongs to the peptidase S1 family. Plasminogen subfamily.Contains 5 kringle domains.Contains 1 PAN domain.Contains 1 peptidase S1 domain.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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