For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 16; NC_007873.1 (71829667..71831074). Location: chromosome: 16

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of AANAT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

AANAT; SNAT

22,891 Da[Similar Products]

serotonin N-acetyltransferase; AA-NAT; serotonin acetylase; arylalkylamine N-acetyltransferase; pineal arylalkylamine N-acetyltransferase

Serotonin N-acetyltransferase

SNAT; Serotonin acetylase; AA-NAT??[Similar Products]

SNAT_MACMU

Function: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. Ref.1

Catalytic activity: Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine.

Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.

Subunit structure: Monomer

By similarity. Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-28

By similarity. Phosphorylation on Ser-202 also allows binding to YWHAZ, but with lower affinity

By similarity. The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation

By similarity.

Subcellular location: Cytoplasm

By similarity.

Tissue specificity: Highly expressed in pineal gland and in the photoreceptor outer segments in the retina. Expressed at about 100-fold lower levels in the pituitary gland and testis. Not detected in other tissues. Ref.1

Induction: Exhibits night/day variations with a 10-fold increased protein levels and activity at night in the pineal gland and a 5-fold increase in the retina. In both tissues, the mRNA levels remain constant. Ref.1

Post-translational modification: cAMP-dependent phosphorylation regulates AANAT activity by promoting interaction with 14-3-3 proteins. Phosphorylation levels exhibit night/day variations, with an increase during nighttime.

Sequence similarities: Belongs to the acetyltransferase family. AANAT subfamily.Contains 1 N-acetyltransferase domain.

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