Full Product Name
CCNT2 Polyclonal Antibody
Product Synonym Names
Cyclin-T2; CycT2; CCNT2
Product Gene Name
anti-CCNT2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O60583
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 510-590
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CCNT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CCNT2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CCNT2 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for CCNT2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001232.1
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NCBI GenBank Nucleotide #
NM_001241.3
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UniProt Primary Accession #
O60583
[Other Products]
UniProt Secondary Accession #
O60582; Q29R66; Q53SR4; Q5I1Y0; A8KA48; D3DP73; D3DP74[Other Products]
UniProt Related Accession #
O60583[Other Products]
NCBI Official Full Name
cyclin-T2 isoform a
NCBI Official Synonym Full Names
cyclin T2
NCBI Official Symbol
CCNT2??[Similar Products]
NCBI Official Synonym Symbols
CYCT2
??[Similar Products]
NCBI Protein Information
cyclin-T2
UniProt Protein Name
Cyclin-T2
UniProt Gene Name
CCNT2??[Similar Products]
UniProt Synonym Gene Names
CycT2??[Similar Products]
NCBI Summary for CCNT2
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
UniProt Comments for CCNT2
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development ().
Research Articles on CCNT2
1. miR-192 inhibits cell proliferation and induces G0/G1 cell cycle arrest in AML by regulating the expression of CCNT2.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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