Product Name
4-hydroxybenzoate polyprenyltransferase (Coq2), Recombinant Protein
Full Product Name
Recombinant Mouse 4-hydroxybenzoate polyprenyltransferase, mitochondrial (Coq2)
Product Gene Name
Coq2 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
35-374aa; full length protein
Sequence
AGVPGARDRR APAPGTQRGR ALSLSAAAVV NSAPRPLQPY LRLMRLDKPI GTWLLYLPCT WSIGLAADPG CFPDWYMLSL FGTGAILMRG AGCTINDMWD RDFDKKVTRT ANRPIAAGDI STFQSFVFLG GQLTLALGVL LCLNYYSIAM GAASLLLVVT YPLVKRITFW PQLALGLTFN WGALLGWSAV KGSCDPAVCL PLYFSGVMWT LIYDTIYAHQ DKKDDALIGL KSTALLFQEN TRQWLSGFGV AMVAALSLAG ANNGQTVPYY AAVAAVGAHL AHQIYTVDIH RAEDCWDKFT SNRTVGMLLF LGIVLGNLCK EKTEEAKDAE AVRVGSEQTS
3D Structure
ModBase 3D Structure for Q66JT7
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Coq2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Coq2 recombinant protein
Transmembrane Protein
Application Notes for Coq2 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Coq2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_082254.2
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NCBI GenBank Nucleotide #
NM_027978.2
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UniProt Primary Accession #
Q66JT7
[Other Products]
UniProt Secondary Accession #
Q9D7M9; E9QPH1[Other Products]
UniProt Related Accession #
Q66JT7[Other Products]
Molecular Weight
40,504 Da
NCBI Official Full Name
4-hydroxybenzoate polyprenyltransferase, mitochondrial
NCBI Official Synonym Full Names
coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
NCBI Official Symbol
Coq2??[Similar Products]
NCBI Official Synonym Symbols
PHB:PPT; 2310002F18Rik
??[Similar Products]
NCBI Protein Information
4-hydroxybenzoate polyprenyltransferase, mitochondrial
UniProt Protein Name
4-hydroxybenzoate polyprenyltransferase, mitochondrial
UniProt Synonym Protein Names
Para-hydroxybenzoate--polyprenyltransferase
UniProt Gene Name
Coq2??[Similar Products]
UniProt Synonym Gene Names
4-HB polyprenyltransferase; PHB:PPT; PHB:polyprenyltransferase??[Similar Products]
UniProt Entry Name
COQ2_MOUSE
UniProt Comments for Coq2
COQ2: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB. Defects in COQ2 are the cause of coenzyme Q10 deficiency, primary, type 1 (COQ10D1). An autosomal recessive disorder with variable manifestations consistent with 5 major phenotypes. The phenotypes include an encephalomyopathic form with seizures and ataxia; a multisystem infantile form with encephalopathy, cardiomyopathy and renal failure; a predominantly cerebellar form with ataxia and cerebellar atrophy; Leigh syndrome with growth retardation; and an isolated myopathic form. Belongs to the UbiA prenyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Mitochondrial; Transferase; EC 2.5.1.39; Membrane protein, integral; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis
Cellular Component: integral to membrane; membrane; mitochondrial inner membrane; mitochondrion
Molecular Function: 4-hydroxybenzoate decaprenyltransferase activity; 4-hydroxybenzoate nonaprenyltransferase activity; prenyltransferase activity; transferase activity
Biological Process: glycerol metabolic process; isoprenoid biosynthetic process; ubiquinone biosynthetic process
Research Articles on Coq2
1. Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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