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4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2), ELISA Kit

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產(chǎn)品名稱: 4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2), ELISA Kit
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4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2), ELISA Kit


4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2), ELISA Kit  的詳細(xì)介紹
Product Name

4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2), ELISA Kit

Full Product Name

Monkey 4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2) ELISA Kit

Product Gene Name

COQ2 elisa kit

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Request for Current Manual Insert
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OMIM
609825
Species Reactivity
Monkey
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
Preparation and Storage
Store all reagents at 2-8 degree C.
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of COQ2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for COQ2 purchase
MBS7206729 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COQ2. The ELISA analytical biochemical technique of the MBS7206729 kit is based on COQ2 antibody-COQ2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COQ2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COQ2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for COQ2. It may not necessarily be applicable to this product.
NCBI GI #
260656052
NCBI GeneID
27235
NCBI Accession #
NP_056512.5 [Other Products]
NCBI GenBank Nucleotide #
NM_015697.7 [Other Products]
UniProt Secondary Accession #
O95331; Q1JQ78; Q684R2[Other Products]
UniProt Related Accession #
Q96H96[Other Products]
Molecular Weight
35,468 Da
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NCBI Official Full Name
4-hydroxybenzoate polyprenyltransferase, mitochondrial
NCBI Official Synonym Full Names
coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
NCBI Official Symbol
COQ2??[Similar Products]
NCBI Official Synonym Symbols
MSA1; CL640; COQ10D1
??[Similar Products]
NCBI Protein Information
4-hydroxybenzoate polyprenyltransferase, mitochondrial; PHB:polyprenyltransferase; coenzyme Q2 homolog, prenyltransferase; para-hydroxybenzoate-polyprenyltransferase, mitochondrial
UniProt Protein Name
4-hydroxybenzoate polyprenyltransferase, mitochondrial
UniProt Synonym Protein Names
COQ2 homolog; hCOQ2; Para-hydroxybenzoate--polyprenyltransferase; PHB:polyprenyltransferase
UniProt Gene Name
COQ2??[Similar Products]
UniProt Synonym Gene Names
CL640; hCOQ2; PHB:polyprenyltransferase??[Similar Products]
UniProt Entry Name
COQ2_HUMAN
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NCBI Summary for COQ2
This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. [provided by RefSeq, Oct 2009]
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UniProt Comments for COQ2
COQ2: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB. Defects in COQ2 are the cause of coenzyme Q10 deficiency, primary, type 1 (COQ10D1). An autosomal recessive disorder with variable manifestations consistent with 5 major phenotypes. The phenotypes include an encephalomyopathic form with seizures and ataxia; a multisystem infantile form with encephalopathy, cardiomyopathy and renal failure; a predominantly cerebellar form with ataxia and cerebellar atrophy; Leigh syndrome with growth retardation; and an isolated myopathic form. Belongs to the UbiA prenyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; EC 2.5.1.39

Chromosomal Location of Human Ortholog: 4q21.23

Cellular Component: mitochondrial inner membrane; integral to membrane

Molecular Function: 4-hydroxybenzoate decaprenyltransferase activity; 4-hydroxybenzoate nonaprenyltransferase activity

Biological Process: ubiquinone biosynthetic process; isoprenoid biosynthetic process; glycerol metabolic process

Disease: Multiple System Atrophy 1, Susceptibility To; Coenzyme Q10 Deficiency, Primary, 1
Research Articles on COQ2
1. The recessive COQ2 mutations recently were nominated to be the genetic cause in a subset of familial and sporadic MSA cases.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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