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DAP12, Polyclonal Antibody

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產(chǎn)品名稱: DAP12, Polyclonal Antibody
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DAP12, Polyclonal Antibody


DAP12, Polyclonal Antibody  的詳細(xì)介紹
Product Name

DAP12, Polyclonal Antibody

Full Product Name

Anti-DAP12 Antibody (aa85-113) IHC-plus

Product Synonym Names
Rabbit Polyclonal to Human DAP12; Human DAP12; DNAX-activation protein 12; PLOSL; KARAP; KAR-associated protein; PLO-SL
Product Gene Name

anti-DAP12 antibody

[Similar Products]
Product Synonym Gene Name
TYROBP[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
221770
3D Structure
ModBase 3D Structure for O43914
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
Human DAP12
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.09% sodium azide
Immunogen
DAP12 antibody was raised against kLH-conjugated synthetic peptide from C-terminal region of human TYROBP.
Immunogen Description
KLH-conjugated synthetic peptide from C-terminal region of human TYROBP.
Immunogen Type
Synthetic peptide
Antigen Modification
aa85-113
Target Species
Human
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.
Other Notes
Small volumes of anti-DAP12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-DAP12 antibody
TYROBP Antibody, DNAX-activation protein 12 Antibody, DAP12 Antibody, PLOSL Antibody, KARAP Antibody, KAR-associated protein Antibody, PLO-SL Antibody Description: DAP12 is a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element.
Applications Tested/Suitable for anti-DAP12 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-DAP12 antibody
Flow Cytometry (1:10 - 1:50)
IHC-P (1:100)
WB (1:1000)

Immunohistochemistry (IHC) of anti-DAP12 antibody
Anti-DAP12 antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
anti-DAP12 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-DAP12 antibody
Western blot of TYROBP Antibody in HepG2 cell line lysates (35 ug/lane). TYROBP (arrow) was detected using the purified antibody.
anti-DAP12 antibody Western Blot (WB) (WB) image
Flow Cytometry (FC/FACS) of anti-DAP12 antibody
TYROBP Antibody flow cytometry of HepG2 cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-DAP12 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for DAP12. It may not necessarily be applicable to this product.
NCBI GI #
4507755
NCBI GeneID
7305
NCBI Accession #
NP_003323.1 [Other Products]
NCBI GenBank Nucleotide #
NM_003332.3 [Other Products]
UniProt Primary Accession #
O43914 [Other Products]
UniProt Secondary Accession #
Q6FGA5; Q9UMT3; A8K2X0; F5H389[Other Products]
UniProt Related Accession #
O43914[Other Products]
Molecular Weight
11,043 Da
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NCBI Official Full Name
TYRO protein tyrosine kinase-binding protein isoform 1
NCBI Official Synonym Full Names
TYRO protein tyrosine kinase binding protein
NCBI Official Symbol
TYROBP??[Similar Products]
NCBI Official Synonym Symbols
DAP12; KARAP; PLOSL
??[Similar Products]
NCBI Protein Information
TYRO protein tyrosine kinase-binding protein
UniProt Protein Name
TYRO protein tyrosine kinase-binding protein
UniProt Synonym Protein Names
DNAX-activation protein 12; Killer-activating receptor-associated protein; KAR-associated protein
UniProt Gene Name
TYROBP??[Similar Products]
UniProt Synonym Gene Names
DAP12; KARAP; KAR-associated protein??[Similar Products]
UniProt Entry Name
TYOBP_HUMAN
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NCBI Summary for DAP12
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
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UniProt Comments for DAP12
TYROBP: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. Belongs to the TYROBP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cell surface; integral to plasma membrane; intracellular; plasma membrane

Molecular Function: identical protein binding; protein binding; receptor binding; receptor signaling protein activity

Biological Process: axon guidance; cellular defense response; innate immune response; integrin-mediated signaling pathway; macrophage activation during immune response; neutrophil activation during immune response; regulation of immune response; signal transduction

Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Research Articles on DAP12
1. This study reveled that TYROBP having a central role in the bipolar disease and schizophrenia manifestation.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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