TYRO protein tyrosine kinase-binding protein; DNAX-activation protein 12; Killer-activating receptor-associated protein; KARAP; TYROBP

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 7; NC_000073.6 (30413788..30417582). Location: 7 B; 7 17.45 cM

Polyclonal

Rabbit

Ammonium Sulfate Precipitation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles.

Small volumes of anti-DAP12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells (1,2). DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction (3). Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice (4,5), as well as presenile dementia and bone cysts in humans (6).

Polyclonal Antibody; Protein Kinases

Western Blot (WB), Immunoprecipitation (IP)

Immunoprecipitation using DAP12 antibody on MHC class I (1) and NKp44 (2) positive cells.

12,367 Da

TYRO protein tyrosine kinase binding protein

TYRO protein tyrosine kinase-binding protein; KAR-associated protein; DNAX-activation protein 12; killer-activating receptor-associated protein; killer cell activating receptor associated protein

TYRO protein tyrosine kinase-binding protein

Dap12; Karap; KAR-associated protein??[Similar Products]

TYOBP_MOUSE

Function: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. Ref.7

Subunit structure: Homodimer; disulfide-linked. Interacts with SIRPB1 and TREM1. Interacts with SIGLEC14

By similarity. Interacts with CLECSF5. Interacts with CD300LB and CD300D. Interacts with CD300E. Interacts with KLRC2 and KIR2DS3

By similarity. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK mediating neutrophils and macrophages integrin-mediated activation. Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.10

Subcellular location: Membrane; Single-pass type I membrane protein.

Post-translational modification: Tyrosine phosphorylated.

Sequence similarities: Belongs to the TYROBP family.Contains 1 ITAM domain.

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.