IL1R8; IL1RAPL; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2; OTTHUMP00000023097|X-linked interleukin-1 receptor accessory protein-like 1|interleukin 1 receptor-8|mental retardation; X-linked 10|oligophreni

For Research Use Only. Not for use in diagnostic procedures.

This assay has high sensitivity and excellent specificity for detection of Human IL1RAPL1. No significant cross-reactivity or interference between Human IL1RAPL1 and analogues was observed.

Store at 2-8 degree C.

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Small volumes of IL1RAPL1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS283828 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interleukin-1 (IL1RAPL1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IL1RAPL1. The ELISA analytical biochemical technique of the MBS283828 kit is based on IL1RAPL1 antibody-IL1RAPL1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IL1RAPL1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IL1RAPL1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate IL1RAPL1 in samples. An antibody specific for IL1RAPL1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyIL1RAPL1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for IL1RAPL1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of IL1RAPL1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

79,969 Da

interleukin 1 receptor accessory protein like 1

interleukin-1 receptor accessory protein-like 1

Interleukin-1 receptor accessory protein-like 1

OPHN4; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; TIGIRR-2??[Similar Products]

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017]

IL1RAPL1: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: Xp21.3-p21.2

Cellular Component: axon; cell surface; cytoplasm; dendrite; integral component of membrane; plasma membrane; postsynaptic membrane

Molecular Function: interleukin-1 binding; protein binding; receptor binding; voltage-gated calcium channel activity

Biological Process: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; negative regulation of exocytosis; neuron differentiation; positive regulation of dendrite morphogenesis; positive regulation of synaptogenesis; signal transduction

Disease: Mental Retardation, X-linked 21

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