Product Name
Interleukin-1 receptor accessory protein-like 1 (Il1rapl1), Recombinant Protein
Full Product Name
Interleukin-1 receptor accessory protein-like 1
Product Gene Name
Il1rapl1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
25-696. Full Length of Mature Protein
Sequence
RGSADGCTDW SVDIKKYQVL VGEPVRIKCA LFYGYIRTNY TLAQSAGLSL MWYKSSGPGD FEEPIAFDGS RMSKEEDSIW FRPTLLQDSG LYACVIRNST YCMKVSISLT VGENDTGLCY NSKMKYFEKA ELSKSKEISC RDIEDFLLPT REPEILWYKE CRTKTWRPSI VFKRDTLLIK EVKEDDIGNY TCELKYGGFV VRRTTELTVT APLTDKPPKL LYPMESKLTI QETQLGGSAN LTCRAFFGYS GDVSPLIYWM KGEKFIEDLD ENRVWESDIR ILKEHLGEQE VSISLIVDSV EEGDLGNYSC YVENGNGRRH ASVLLHKREL MYTVELAGGL GAILLLLVCS VTIYKCYKIE IMLFYRNHFG AEELDGDNKD YDAYLSYTKV DPDQWNQETG EEERFALEIL PDMLEKHYGY KLFIPDRDLI PTGTYIEDVA RCVDQSKRLI IVMTPNYVVR RGWSIFELET RLRNMLVTGE IKVILIECSE LRGIMNYQEV EALKHTIKLL TVIKWHGPKC NKLNSKFWKR LQYEMPFKRI EPITHEQALD VSEQGPFGEL QTVSAISMAA ATSTALATAH PDLRSTFHNT YHSQMRQKHY YRSYEYDVPP TGTLPLTSIG NQHTYCNIPM TLINGQRPQT KSSREPNPDE AHTNSAILPL LARETSISSV IW
3D Structure
ModBase 3D Structure for P59824
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Rattus norvegicus (Rat)
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Il1rapl1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Il1rapl1 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Product Categories/Family for Il1rapl1 recombinant protein
Transmembrane Protein
NCBI/Uniprot data below describe general gene information for Il1rapl1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_808796.1
[Other Products]
NCBI GenBank Nucleotide #
NM_177935.2
[Other Products]
UniProt Primary Accession #
P59824
[Other Products]
UniProt Related Accession #
P59824[Other Products]
Molecular Weight
79,771 Da
NCBI Official Full Name
interleukin-1 receptor accessory protein-like 1
NCBI Official Synonym Full Names
interleukin 1 receptor accessory protein-like 1
NCBI Official Symbol
Il1rapl1??[Similar Products]
NCBI Official Synonym Symbols
Il1rapl
??[Similar Products]
NCBI Protein Information
interleukin-1 receptor accessory protein-like 1
UniProt Protein Name
Interleukin-1 receptor accessory protein-like 1
UniProt Synonym Protein Names
X-linked interleukin-1 receptor accessory protein-like 1
Protein Family
Interleukin-1 receptor accessory protein
UniProt Gene Name
Il1rapl1??[Similar Products]
UniProt Synonym Gene Names
IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1??[Similar Products]
UniProt Entry Name
IRPL1_RAT
NCBI Summary for Il1rapl1
member of the interleukin 1 receptor family; mutation of human homolog may be involved is associated with X-linked mental retardation [RGD, Feb 2006]
UniProt Comments for Il1rapl1
IL1RAPL1: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: cell surface; dendrite; plasma membrane
Molecular Function: interleukin-1 binding; receptor binding; voltage-gated calcium channel activity
Biological Process: heterophilic cell adhesion; negative regulation of exocytosis; neuron differentiation; positive regulation of dendrite morphogenesis
Research Articles on Il1rapl1
1. interaction of IL1RAPL1 with PSD-95 discloses a novel pathophysiological mechanism of cognitive impairment associated with alterations of the JNK pathway leading to a mislocalization of PSD-95 and abnormal synaptic organization and function
Precautions
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Disclaimer
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