HMGCR

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous level of total 3-hydroxy-3 methylglutaryl-coenzyme A reductase polyclonal antibody.

Caprylic Acid Ammonium Sulfate Precipitation purified

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

1.0 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-HMGCR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Total protein Ab

Western Blot (WB), Immunohistochemistry (IHC)

Western Blot: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

All lanes: 3-hydroxy-3 methylglutaryl-coenzyme A reductase antibody at 2ug/ml

Immunohistochemical analysis of paraffin-embedded human placenta using at dilution of 1:20.

99,752 Da[Similar Products]

3-hydroxy-3-methylglutaryl-CoA reductase

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

3-hydroxy-3-methylglutaryl-coenzyme A reductase

HMG-CoA reductase??[Similar Products]

HMDH_HUMAN

HMGCR: the rate-limiting enzyme for cholesterol synthesis. Regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by this reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.

Protein type: EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis

Chromosomal Location of Human Ortholog: 5q13.3-q14

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; peroxisomal membrane

Molecular Function: coenzyme binding; hydroxymethylglutaryl-CoA reductase (NADPH) activity; hydroxymethylglutaryl-CoA reductase activity; protein binding

Biological Process: cholesterol biosynthetic process; isoprenoid biosynthetic process; protein tetramerization

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