Product Name
6CKine, Polyclonal Antibody
Full Product Name
6CKine Polyclonal Antibody
Product Synonym Names
C-C motif chemokine 21; Beta-chemokine exodus-2; Secondary lymphoid-tissue chemokine; SLC; Small-inducible cytokine A21; CCL21; SCYA21; UNQ784/PRO1600
Product Gene Name
anti-6Ckine antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O00585
Purity/Purification
Affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Immunogen
Synthetic peptide from human protein at AA range: 71-120
Storage Buffer
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-6Ckine antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-6Ckine antibody
Immunohistochemistry (IHC) Paraffin, ELISA (EIA)
Application Notes for anti-6Ckine antibody
IHC-p: 1:50-200
ELISA: 1:10000-20000
NCBI/Uniprot data below describe general gene information for 6Ckine. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002980.1
[Other Products]
NCBI GenBank Nucleotide #
NM_002989.3
[Other Products]
UniProt Primary Accession #
O00585
[Other Products]
UniProt Secondary Accession #
Q6ICR7[Other Products]
UniProt Related Accession #
O00585[Other Products]
Molecular Weight
14,646 Da
NCBI Official Full Name
C-C motif chemokine 21
NCBI Official Synonym Full Names
C-C motif chemokine ligand 21
NCBI Official Symbol
CCL21??[Similar Products]
NCBI Official Synonym Symbols
ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21
??[Similar Products]
NCBI Protein Information
C-C motif chemokine 21
UniProt Protein Name
C-C motif chemokine 21
UniProt Synonym Protein Names
6Ckine; Beta-chemokine exodus-2; Secondary lymphoid-tissue chemokine; SLC; Small-inducible cytokine A21
UniProt Gene Name
CCL21??[Similar Products]
UniProt Synonym Gene Names
SCYA21; SLC??[Similar Products]
NCBI Summary for 6Ckine
This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]
UniProt Comments for 6Ckine
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Research Articles on 6Ckine
1. The research findings demonstrate for the first time that the chemokines CCL19, CCL21 and CCR7 play important roles in bone destruction by increasing osteoclast migration and resorption activity, and that has been linked to rheumatoid arthritis pathogenesis.
Precautions
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Disclaimer
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