C-C motif chemokine 21 (6Ckine) (Beta-chemokine exodus-2) (Secondary lymphoid-tissue chemokine) (SLC) (Small-inducible cytokine A21)

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity Purification

1mg/mL (lot specific)

Store at -20 degree C. Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-6CKine antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

Immunohistochemistry (IHC) Paraffin, ELISA (EIA)

IHC: 1:50-200
ELISA: 1:10000-20000

Immunohistochemistry of paraffin-embedded Human lymph tissue using 6CKine Polyclonal Antibody at dilution of 1:200.

Immunohistochemistry of paraffin-embedded Human colon cancer tissue using 6CKine Polyclonal Antibody at dilution of 1:200.

14,646 Da

C-C motif chemokine ligand 21

C-C motif chemokine 21

C-C motif chemokine 21

SCYA21; SLC??[Similar Products]

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]

CCL21: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: cell; extracellular region; extracellular space

Molecular Function: CCR chemokine receptor binding; CCR7 chemokine receptor binding; chemokine activity; chemokine receptor binding; protein binding

Biological Process: cell maturation; cell-cell signaling; dendritic cell chemotaxis; establishment of T cell polarity; formation of immunological synapse; G-protein coupled receptor signaling pathway; immune response; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; positive regulation of actin filament polymerization; positive regulation of cell adhesion mediated by integrin; positive regulation of cell-matrix adhesion; positive regulation of chemotaxis; positive regulation of dendritic cell antigen processing and presentation; positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of JNK cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of pseudopodium assembly; positive regulation of receptor-mediated endocytosis; release of sequestered calcium ion into cytosol; ruffle organization; T cell costimulation

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