Product Name
A1CF, cDNA Clone
Full Product Name
A1CF cDNA Clone
Product Gene Name
A1CF cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggaatcaa atcacaaatc cggggatgga ttgagcggca ctcagaagga agcagccctc cgcgcactgg tccagcgcac aggatatagc ttggtccagg aaaatggaca aagaaaatat ggtggccctc cacctggttg ggatgctgca ccccctgaaa ggggctgtga aatttttatt ggaaaacttc cccgagacct ttttgaggat gagcttatac cattatgtga aaaaatcggt aaaatttatg aaatgagaat gatgatggat tttaatggca acaatagagg atatgcattt gtaacatttt caaataaagt ggaagccaag aatgcaatca agcaacttaa taattatgaa attagaaatg ggcgcctctt aggggtttgt gccagtgtgg acaactgccg attatttgtt gggggcatcc caaaaaccaa aaagagagaa gaaatcttat cggagatgaa aaaggttact gaaggtgttg tcgatgtcat cgtctaccca agcgctgcag ataaaaccaa aaaccgaggc tttgccttcg tggagtatga gagtcatcga gcagctgcca tggcgaggag gaaactgcta ccaggaagaa ttcagttatg gggacatggt attgcagtag actgggcaga gccagaagta gaagttgatg aagatacaat gtcttcagtg aaaatcctat atgtaagaaa tcttatgctg tctacctctg aagagatgat tgaaaaggaa ttcaacaata tcaaaccagg tgctgtggag agggtgaaga aaattcgaga ctatgctttt gtgcacttca gtaaccgaga agatgcagtt gaggctatga aagctttaaa tggcaaggtg ctggatggtt cccccattga agtcacccta gcaaaaccag tggacaagga cagttatgtt aggtataccc gaggcacagg tggaaggggc accatgctgc aaggagagta tacctactct ttgggccaag tttatgatcc caccacaacc taccttggag ctcctgtctt ctatgccccc cagacctatg cagcaattcc cagtcttcat ttcccagcca ccaaaggaca tctcagcaac agagccatta tccgagcccc ttctgttaga gaaatttaca tgaatgtacc tgtaggggct gcgggagtga gaggactggg cggccgtggc tatttggcat acacaggcct gggtcgagga taccaggtca aaggagacaa aagagaagac aaactctatg acattttacc tgggatggag ctcaccccaa tgaatcctgt cacattaaaa ccccaaggaa ttaaactcgc tccccagata ttagaagaga tttgtcagaa aaataactgg ggacagccag tgtaccagct gcactctgct attggacaag accaaagaca gctattcttg tacaaaataa ctattcctgc tctagccagc cagaatcctg caatccaccc tttcacacct ccaaagctga gtgcctttgt ggatgaagca aagacgtatg cagccgaata caccctgcag accctgggca tccccactga tggaggcgat ggcaccatgg ctactgctgc tgctgctgct actgctttcc caggatatgc tgtccctaat gcaactgcac ccgtgtctgc agcccagctc aagcaagcgg taacccttgg acaagactta gcagcatata caacctatga ggtctaccca acttttgcag tgactgcccg aggggatgga tatggcacct tctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of A1CF cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for A1CF. It may not necessarily be applicable to this product.
NCBI Accession #
BC130519
[Other Products]
UniProt Secondary Accession #
Q5SZQ0; Q9NQ93; Q9NQX8; Q9NQX9; Q9NXC9; Q9NZD3; A1L4F2; A8K7G7; B7ZM14[Other Products]
UniProt Related Accession #
Q9NQ94[Other Products]
Molecular Weight
58,871 Da
NCBI Official Full Name
Homo sapiens APOBEC1 complementation factor, mRNA
NCBI Official Synonym Full Names
APOBEC1 complementation factor
NCBI Official Symbol
A1CF??[Similar Products]
NCBI Official Synonym Symbols
ACF; ASP; ACF64; ACF65; APOBEC1CF
??[Similar Products]
NCBI Protein Information
APOBEC1 complementation factor
UniProt Protein Name
APOBEC1 complementation factor
UniProt Synonym Protein Names
APOBEC1-stimulating protein
Protein Family
APOBEC1 complementation factor
UniProt Gene Name
A1CF??[Similar Products]
UniProt Synonym Gene Names
??[Similar Products]
UniProt Entry Name
A1CF_HUMAN
NCBI Summary for A1CF
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Comments for A1CF
ACF: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA processing; RNA-binding; Hydrolase
Chromosomal Location of Human Ortholog: 10q11.23
Cellular Component: apolipoprotein B mRNA editing enzyme complex; cytoplasm; nucleoplasm
Molecular Function: double-stranded RNA binding; protein binding; RNA binding; single-stranded RNA binding
Biological Process: cytidine to uridine editing; protein stabilization
Research Articles on A1CF
1. hnRNP K and hnRNP L may serve as A1CF-like cofactors in AID-mediated class switch recombination and somatic hypermutation
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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