Product Name
15-hydroxyprostaglandin dehydrogenase [NAD (+)] (Hpgd), Recombinant Protein
Full Product Name
Recombinant Rat 15-hydroxyprostaglandin dehydrogenase [NAD (+)] (Hpgd)
Product Gene Name
Hpgd recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-266aa, Full length protein
Sequence
MHVNGKVALV TGAAQGIGKA FTEALLLHGA KVALVDWNLE TGVKCKAALD EQFEPQKTLF IQCDVADQKQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW EQTLQINLVS VISGTYLGLD YMSKQNGGEG GIIINISSIA GLMPVAQQPV YCASKHGIIG FTRSAAMAAN LMKSGVRLNV ICPGFVKTPI LESIEKEENM GQYIEYTDQI KAMMKFYGIL DPSAIANGLI NLIEDDALNG AIMKITASKG IHFQDYDLFP SFSKAP
3D Structure
ModBase 3D Structure for O08699
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Hpgd recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Hpgd recombinant protein
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for Hpgd. It may not necessarily be applicable to this product.
NCBI Accession #
NP_077366.2
[Other Products]
NCBI GenBank Nucleotide #
NM_024390.2
[Other Products]
UniProt Primary Accession #
O08699
[Other Products]
UniProt Secondary Accession #
Q6P687[Other Products]
UniProt Related Accession #
O08699[Other Products]
Molecular Weight
28,939 Da
NCBI Official Full Name
15-hydroxyprostaglandin dehydrogenase
NCBI Official Synonym Full Names
15-hydroxyprostaglandin dehydrogenase
NCBI Official Symbol
Hpgd??[Similar Products]
NCBI Protein Information
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
UniProt Protein Name
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
UniProt Synonym Protein Names
Prostaglandin dehydrogenase 1
Protein Family
15-hydroxyprostaglandin dehydrogenase
UniProt Gene Name
Hpgd??[Similar Products]
UniProt Synonym Gene Names
Pgdh1; 15-PGDH??[Similar Products]
NCBI Summary for Hpgd
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase [RGD, Feb 2006]
UniProt Comments for Hpgd
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 ().
Research Articles on Hpgd
1. Results showed that 15-PGDH mRNA and protein expression was reduced in the hypothalamus and lungs in stressed animals compared with controls, which was correlated with a reduction of enzymatic activity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
