Product Name
2B4 / SLAMF / CD244, Recombinant Protein
Full Product Name
Recombinant Human 2B4 / SLAMF / CD244 Protein (His tag)
Product Synonym Names
2B4, CD244, NAIL, Nmrk, NKR2B4, SLAMF4
Product Gene Name
2B4 / SLAMF / CD244 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BZW8
Purity/Purification
> 95 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Predicted N Terminal
Cys 22
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of 2B4 / SLAMF / CD244 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
2B4 / SLAMF / CD244 recombinant protein
Background: The CD244 antigen
Description: A DNA sequence encoding the extracellular domain (Met 1-Arg 221) of human 2B4 (NP_057466.1) was expressed, with a polyhistidine tag at the C-terminus.
Application Notes for 2B4 / SLAMF / CD244 recombinant protein
The recombinant 2B4 comprises 211 amino acids and predicts a molecular mass of 23.8 kDa. As a result of glycosylation, the rh 2B4 protein migrates as an approximately 45-50 kDa band in SDS-PAGE under reducing conditions.
SDS-PAGE of 2B4 / SLAMF / CD244 recombinant protein
NCBI/Uniprot data below describe general gene information for 2B4 / SLAMF / CD244. It may not necessarily be applicable to this product.
NCBI Accession #
NP_057466.1
[Other Products]
NCBI GenBank Nucleotide #
NM_016382.3
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UniProt Primary Accession #
Q9BZW8
[Other Products]
UniProt Secondary Accession #
Q5VYI2; Q5VYI6; Q5VYI7; Q96T47; Q9NQD2; Q9NQD3; Q9Y288[Other Products]
UniProt Related Accession #
Q9BZW8[Other Products]
Molecular Weight
30,784 Da
NCBI Official Full Name
natural killer cell receptor 2B4 isoform 1
NCBI Official Synonym Full Names
CD244 molecule
NCBI Official Symbol
CD244??[Similar Products]
NCBI Official Synonym Symbols
2B4; NAIL; Nmrk; NKR2B4; SLAMF4
??[Similar Products]
NCBI Protein Information
natural killer cell receptor 2B4
UniProt Protein Name
Natural killer cell receptor 2B4
UniProt Synonym Protein Names
NK cell activation-inducing ligand; NAIL; NK cell type I receptor protein 2B4; NKR2B4; h2B4; SLAM family member 4; SLAMF4; Signaling lymphocytic activation molecule 4; CD_antigen: CD244
UniProt Gene Name
CD244??[Similar Products]
UniProt Synonym Gene Names
2B4; NAIL; NKR2B4; h2B4; SLAMF4??[Similar Products]
NCBI Summary for 2B4 / SLAMF / CD244
This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for 2B4 / SLAMF / CD244
CD244: Modulate other receptor-ligand interactions to enhance leukocyte activation. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: external side of plasma membrane; plasma membrane
Molecular Function: MHC class I protein binding; protein binding
Biological Process: leukocyte migration; natural killer cell activation during immune response; signal transduction
Disease: Rheumatoid Arthritis
Research Articles on 2B4 / SLAMF / CD244
1. SLAMF4 gene and surface protein expression was down-regulated in CD8+ T cells from SLE patients compared with that in cells obtained from healthy donors. SLAMF4+ effector memory cells produced more granzyme B and perforin than SLAMF4- cells.
Precautions
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Disclaimer
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