Product Name
2B4 / SLAMF / CD244, Recombinant Protein
Full Product Name
Recombinant Human 2B4 / SLAMF / CD244 Protein (Fc tag)
Product Synonym Names
2B4 / CD244, CD244, NAIL, Nmrk, NKR2B4 / CD244, SLAMF4
Product Gene Name
2B4 / SLAMF / CD244 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BZW8
Purity/Purification
> 97 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Predicted N Terminal
Cys 22
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of 2B4 / SLAMF / CD244 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
2B4 / SLAMF / CD244 recombinant protein
Background: The CD244 antigen
Description: A DNA sequence encoding the extracellular domain (Met 1-Arg221) of human 2B4 / CD244 (NP_057466.1) precursor was expressed with the C-terminal fused Fc region of human IgG1.
Application Notes for 2B4 / SLAMF / CD244 recombinant protein
The recombinant 2B4/CD244/Fc chimera is a disulfide-linked homodimer. The reduced monomer comprises 438 amino acids and predicts a molecular mass of 49 kDa. As a result of glycosylation, the rh2B4/CD244/Fc monomer migrates as an approximately 70-80 kDa band in SDS-PAGE under reducing conditions.
SDS-PAGE of 2B4 / SLAMF / CD244 recombinant protein
NCBI/Uniprot data below describe general gene information for 2B4 / SLAMF / CD244. It may not necessarily be applicable to this product.
NCBI Accession #
NP_057466.1
[Other Products]
NCBI GenBank Nucleotide #
NM_016382.3
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UniProt Primary Accession #
Q9BZW8
[Other Products]
UniProt Secondary Accession #
Q5VYI2; Q5VYI6; Q5VYI7; Q96T47; Q9NQD2; Q9NQD3; Q9Y288[Other Products]
UniProt Related Accession #
Q9BZW8[Other Products]
Molecular Weight
30,784 Da
NCBI Official Full Name
natural killer cell receptor 2B4 isoform 1
NCBI Official Synonym Full Names
CD244 molecule
NCBI Official Symbol
CD244??[Similar Products]
NCBI Official Synonym Symbols
2B4; NAIL; Nmrk; NKR2B4; SLAMF4
??[Similar Products]
NCBI Protein Information
natural killer cell receptor 2B4
UniProt Protein Name
Natural killer cell receptor 2B4
UniProt Synonym Protein Names
NK cell activation-inducing ligand; NAIL; NK cell type I receptor protein 2B4; NKR2B4; h2B4; SLAM family member 4; SLAMF4; Signaling lymphocytic activation molecule 4; CD_antigen: CD244
UniProt Gene Name
CD244??[Similar Products]
UniProt Synonym Gene Names
2B4; NAIL; NKR2B4; h2B4; SLAMF4??[Similar Products]
NCBI Summary for 2B4 / SLAMF / CD244
This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for 2B4 / SLAMF / CD244
CD244: Modulate other receptor-ligand interactions to enhance leukocyte activation. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: external side of plasma membrane; plasma membrane
Molecular Function: MHC class I protein binding; protein binding
Biological Process: leukocyte migration; natural killer cell activation during immune response; signal transduction
Disease: Rheumatoid Arthritis
Research Articles on 2B4 / SLAMF / CD244
1. SLAMF4 gene and surface protein expression was down-regulated in CD8+ T cells from SLE patients compared with that in cells obtained from healthy donors. SLAMF4+ effector memory cells produced more granzyme B and perforin than SLAMF4- cells.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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