Full Product Name
Anti-MYO7A Antibody
Product Synonym Names
USH1B; Unconventional myosin-VIIa
Product Gene Name
anti-MYO7A antibody
[Similar Products]
Antibody/Peptide Pairs
MYO7A peptide (MBS823432) is used for blocking the activity of MYO7A antibody (MBS821898)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13402
Species Reactivity
Human, Mouse, Rat, Pig
Specificity
Recognizes endogenous levels of MYO7A protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MYO7A. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-MYO7A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MYO7A antibody
Rabbit polyclonal antibody to MYO7A
Applications Tested/Suitable for anti-MYO7A antibody
Western Blot (WB)
Application Notes for anti-MYO7A antibody
WB (1/500 - 1/1000)
Western Blot (WB) of anti-MYO7A antibody
Western blot analysis of MYO7A expression in SKOVCAR (A), HEK293T (B) whole cell lysates.
NCBI/Uniprot data below describe general gene information for MYO7A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000251.3
[Other Products]
NCBI GenBank Nucleotide #
NM_000260.3
[Other Products]
UniProt Primary Accession #
Q13402
[Other Products]
UniProt Secondary Accession #
P78427; Q13321; Q14785; Q92821; Q92822; B9A011; F8VUN5[Other Products]
UniProt Related Accession #
Q13402[Other Products]
Molecular Weight
249,165 Da
NCBI Official Full Name
unconventional myosin-VIIa isoform 1
NCBI Official Synonym Full Names
myosin VIIA
NCBI Official Symbol
MYO7A??[Similar Products]
NCBI Official Synonym Symbols
DFNB2; MYU7A; NSRD2; USH1B; DFNA11; MYOVIIA
??[Similar Products]
NCBI Protein Information
unconventional myosin-VIIa; myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))
UniProt Protein Name
Unconventional myosin-VIIa
Protein Family
Unconventional myosin
UniProt Gene Name
MYO7A??[Similar Products]
UniProt Synonym Gene Names
USH1B??[Similar Products]
UniProt Entry Name
MYO7A_HUMAN
NCBI Summary for MYO7A
This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for MYO7A
MYO7A: an actin-based motor molecule with ATPase activity and a calcium sensitive calmodulin binding subunit. May play a role in trafficking of ribbon- synaptic vesicle complexes and renewal of outer photoreceptor disks. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Seven alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 11q13.5
Cellular Component: stereocilium; photoreceptor inner segment; photoreceptor outer segment; lysosomal membrane; cytoplasm; apical plasma membrane; melanosome; synapse; cell cortex; cytosol; photoreceptor connecting cilium
Molecular Function: actin filament binding; microfilament motor activity; calmodulin binding; protein domain specific binding; protein binding; protein homodimerization activity; spectrin binding; ADP binding; actin-dependent ATPase activity; ATP binding
Biological Process: phagolysosome formation; intracellular protein transport; eye photoreceptor cell development; sensory perception of sound; pigment granule transport; visual perception; lysosome organization and biogenesis; actin filament-based movement; metabolic process; sensory perception of light stimulus; auditory receptor cell stereocilium organization and biogenesis; equilibrioception; post-embryonic organ morphogenesis
Disease: Deafness, Autosomal Recessive 2; Deafness, Autosomal Dominant 11; Usher Syndrome, Type I
Research Articles on MYO7A
1. The MYO7A gene is responsible for two distinct diseases and gives evidence that the p.P1887L mutation in a homozygous state may be responsible for nonsyndromic hearing loss.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
