Full Product Name
MYO7A Polyclonal Antibody
Product Synonym Names
DFNB2; MYU7A; NSRD2; USH1B; DFNA11; MYOVIIA
Product Gene Name
anti-MYO7A antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2mg/mL (lot specific)
Immunogen
Synthetic peptide of human MYO7A
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-MYO7A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MYO7A antibody
This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants.
Applications Tested/Suitable for anti-MYO7A antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-MYO7A antibody
IHC: 1:50-1:200
Immunohistochemistry (IHC) of anti-MYO7A antibody
Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using MYO7A Polyclonal Antibody at dilution 1:30
Immunohistochemistry (IHC) of anti-MYO7A antibody
Immunohistochemistry of paraffin-embedded Human brain tissue using MYO7A Polyclonal Antibody at dilution 1:30
NCBI/Uniprot data below describe general gene information for MYO7A. It may not necessarily be applicable to this product.
NCBI Accession #
AAI72681.1
[Other Products]
UniProt Secondary Accession #
Q5MJ57; E9QLP7[Other Products]
UniProt Related Accession #
P97479[Other Products]
Molecular Weight
251,097 Da
NCBI Official Full Name
Myosin VIIA
NCBI Official Synonym Full Names
myosin VIIA
NCBI Official Symbol
Myo7a??[Similar Products]
NCBI Official Synonym Symbols
Hdb; sh1; Myo7; sh-1; USH1B; polka; nmf371
??[Similar Products]
NCBI Protein Information
unconventional myosin-VIIa; motor protein; shaker 1
UniProt Protein Name
Unconventional myosin-VIIa
Protein Family
Unconventional myosin
UniProt Gene Name
Myo7a??[Similar Products]
UniProt Synonym Gene Names
Myo7??[Similar Products]
UniProt Entry Name
MYO7A_MOUSE
UniProt Comments for MYO7A
MYO7A: an actin-based motor molecule with ATPase activity and a calcium sensitive calmodulin binding subunit. May play a role in trafficking of ribbon- synaptic vesicle complexes and renewal of outer photoreceptor disks. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Seven alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Motor
Cellular Component: photoreceptor inner segment; microvillus; lysosomal membrane; cell; cytosol; stereocilium; cytoskeleton; photoreceptor outer segment; apical plasma membrane; cytoplasm; melanosome; synapse; intracellular; myosin complex; photoreceptor connecting cilium
Molecular Function: protein domain specific binding; protein homodimerization activity; motor activity; nucleotide binding; protein N-terminus binding; ADP binding; actin-dependent ATPase activity; actin binding; calmodulin binding; actin filament binding; microfilament motor activity; protein binding; spectrin binding; protein complex binding; ATP binding
Biological Process: mechanoreceptor differentiation; inner ear morphogenesis; actin filament-based movement; auditory receptor cell differentiation; phagocytosis; phagolysosome formation; intracellular protein transport; sensory perception of sound; pigment granule transport; cell projection organization and biogenesis; inner ear receptor cell differentiation; visual perception; transport; lysosome organization and biogenesis; sensory perception; sensory perception of light stimulus; auditory receptor cell stereocilium organization and biogenesis; equilibrioception; inner ear development; post-embryonic organ morphogenesis; pigment granule localization
Research Articles on MYO7A
1. Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
