Full Product Name
NALP7 Antibody
Product Synonym Names
NLR family pyrin domain containing 7, NLRP7, PYRIN-containing APAF1-like protein 3, PYPAF3, NOD12, CLR19.4, PAN7, HYDM
Product Gene Name
anti-NALP7 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Immunogen Description
Raised against an 18 amino acid peptide near the amino terminus of human NALP7.
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-NALP7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NALP7 antibody
NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1b secretion and is a feedback regulator of interleukin-1b secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.
Product Categories/Family for anti-NALP7 antibody
Total protein Ab
Applications Tested/Suitable for anti-NALP7 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Western Blot (WB) of anti-NALP7 antibody
Western blot analysis of NALP7 in human brain tissue lysate with NALP7 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry (IHC) of anti-NALP7 antibody
Immunohistochemistry of NALP7 in human brain tissue with NALP7 antibody at 10 ug/mL.
NCBI/Uniprot data below describe general gene information for NALP7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_631915
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NCBI GenBank Nucleotide #
NM_139176.3
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UniProt Secondary Accession #
Q32MH8; Q7RTR1; E9PE16[Other Products]
UniProt Related Accession #
Q8WX94[Other Products]
Molecular Weight
118,303 Da
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 7 isoform 1
NCBI Official Synonym Full Names
NLR family, pyrin domain containing 7
NCBI Official Symbol
NLRP7??[Similar Products]
NCBI Official Synonym Symbols
HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4
??[Similar Products]
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 7
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 7
UniProt Synonym Protein Names
Nucleotide-binding oligomerization domain protein 12; PYRIN-containing APAF1-like protein 3
UniProt Gene Name
NLRP7??[Similar Products]
UniProt Synonym Gene Names
NALP7; NOD12; PYPAF3??[Similar Products]
UniProt Entry Name
NALP7_HUMAN
NCBI Summary for NALP7
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for NALP7
NLRP7: Inhibits CASP1/caspase-1-dependent IL1B secretion. Defects in NLRP7 are the cause of hydatidiform mole recurrent type 1 (HYDM1). A disorder characterized by excessive trophoblast development and the presence of a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 19q13.42
Molecular Function: ATP binding
Disease: Hydatidiform Mole, Recurrent, 1
Research Articles on NALP7
1. NLRP7 thus appears to function in chromatin reprogramming and DNA methylation in the germline or early embryonic development.NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation.
Precautions
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Disclaimer
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