3-phosphoinositide dependent protein kinase-1; MGC20087; MGC35290; PDK1; PRO0461; PkB kinase like gene 1|PkB-like 1|protein kinase

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 10; NC_005109.3 (13267428..13330741, complement). Location: 10q12

Store all reagents at 2-8 degree C

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Small volumes of PDPK1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9334552 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 3-phosphoinositide-dependent protein kinase 1 (PDPK1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PDPK1. The ELISA analytical biochemical technique of the MBS9334552 kit is based on PDPK1 antibody-PDPK1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PDPK1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PDPK1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

63,609 Da

3-phosphoinositide dependent protein kinase-1

3-phosphoinositide-dependent protein kinase 1; pkB kinase; protein kinase B kinase

3-phosphoinositide-dependent protein kinase 1

Pdk1; PkB kinase??[Similar Products]

PDPK1_RAT

may catalyze the phosphorylation and activation of protein kinase B [RGD, Feb 2006]

PDK1: an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described.

Protein type: Nuclear receptor co-regulator; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.1; AGC group; PKB family

Cellular Component: focal adhesion; cell projection; cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; phospholipase binding; 3-phosphoinositide-dependent protein kinase activity; kinase activity; protein kinase binding; ATP binding; insulin receptor binding; phospholipase activator activity

Biological Process: focal adhesion formation; epidermal growth factor receptor signaling pathway; regulation of mast cell degranulation; cell migration; transcription, DNA-dependent; activation of protein kinase B; peptidyl-threonine phosphorylation; calcium-mediated signaling; protein amino acid phosphorylation; hyperosmotic response; cellular response to insulin stimulus; regulation of transcription, DNA-dependent; negative regulation of toll-like receptor signaling pathway; negative regulation of protein kinase activity; positive regulation of release of sequestered calcium ion into cytosol; regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transforming growth factor beta receptor signaling pathway

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