Product Name
NLRP7, Polyclonal Antibody
Popular Item
Full Product Name
NLRP7 Polyclonal Antibody
Product Synonym Names
CLR19.4; HYDM; NALP7; NOD12; PAN7; PYPAF3
Product Gene Name
anti-NLRP7 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8WX94
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human NLRP7
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-NLRP7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NLRP7 antibody
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.
Product Categories/Family for anti-NLRP7 antibody
Primary antibody
Applications Tested/Suitable for anti-NLRP7 antibody
Western Blot (WB)
Application Notes for anti-NLRP7 antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-NLRP7 antibody
Western blot analysis of extracts of various cell lines, using NLRP7 Antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 40s.
NCBI/Uniprot data below describe general gene information for NLRP7. It may not necessarily be applicable to this product.
NCBI Accession #
Q8WX94.1
[Other Products]
UniProt Primary Accession #
Q8WX94
[Other Products]
UniProt Secondary Accession #
Q32MH8; Q7RTR1; E9PE16[Other Products]
UniProt Related Accession #
Q8WX94[Other Products]
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 7
NCBI Official Synonym Full Names
NLR family pyrin domain containing 7
NCBI Official Symbol
NLRP7??[Similar Products]
NCBI Official Synonym Symbols
HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4
??[Similar Products]
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 7
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 7
UniProt Synonym Protein Names
Nucleotide-binding oligomerization domain protein 12; PYRIN-containing APAF1-like protein 3
Protein Family
NACHT, LRR and PYD domains-containing protein
UniProt Gene Name
NLRP7??[Similar Products]
UniProt Synonym Gene Names
NALP7; NOD12; PYPAF3??[Similar Products]
NCBI Summary for NLRP7
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for NLRP7
NLRP7: Inhibits CASP1/caspase-1-dependent IL1B secretion. Defects in NLRP7 are the cause of hydatidiform mole recurrent type 1 (HYDM1). A disorder characterized by excessive trophoblast development and the presence of a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 19q13.42
Disease: Hydatidiform Mole, Recurrent, 1
Research Articles on NLRP7
1. data underscore the involvement of NLR family pyrin domain containing 7 (NLRP7) in recurrent hydatidiform mole pathophysiology and confirm that DNA methylation of specific regions is critical
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Disclaimer
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