Full Product Name
NLRP7 Antibody
Product Synonym Names
HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4
Product Gene Name
anti-NLRP7 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8WX94
Specificity
The antibody detects endogenous levels of total NLRP7 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
3 mg/ml (lot specific)
Immunogen Description
Synthetic peptide corresponding to residues near the N terminal of human NLR family, pyrin domain containing 7
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-NLRP7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NLRP7 antibody
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.
Product Categories/Family for anti-NLRP7 antibody
Total protein Ab
Applications Tested/Suitable for anti-NLRP7 antibody
Immunohistochemistry (IHC)
Application Notes for anti-NLRP7 antibody
Immunohistochemistry: 1:50-1:200
Immunohistochemistry (IHC) of anti-NLRP7 antibody
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/40.
Immunohistochemistry (IHC) of anti-NLRP7 antibody
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/40.
NCBI/Uniprot data below describe general gene information for NLRP7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001120727.1
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NCBI GenBank Nucleotide #
NM_001127255.1
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UniProt Primary Accession #
Q8WX94
[Other Products]
UniProt Secondary Accession #
Q32MH8; Q7RTR1; E9PE16[Other Products]
UniProt Related Accession #
Q8WX94[Other Products]
Molecular Weight
118,303 Da
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 7 isoform 3
NCBI Official Synonym Full Names
NLR family, pyrin domain containing 7
NCBI Official Symbol
NLRP7??[Similar Products]
NCBI Official Synonym Symbols
HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4
??[Similar Products]
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 7
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 7
UniProt Synonym Protein Names
Nucleotide-binding oligomerization domain protein 12; PYRIN-containing APAF1-like protein 3
Protein Family
NACHT, LRR and PYD domains-containing protein
UniProt Gene Name
NLRP7??[Similar Products]
UniProt Synonym Gene Names
NALP7; NOD12; PYPAF3??[Similar Products]
UniProt Entry Name
NALP7_HUMAN
NCBI Summary for NLRP7
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for NLRP7
NLRP7: Inhibits CASP1/caspase-1-dependent IL1B secretion. Defects in NLRP7 are the cause of hydatidiform mole recurrent type 1 (HYDM1). A disorder characterized by excessive trophoblast development and the presence of a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 19q13.42
Molecular Function: ATP binding
Disease: Hydatidiform Mole, Recurrent, 1
Research Articles on NLRP7
1. NLRP7 thus appears to function in chromatin reprogramming and DNA methylation in the germline or early embryonic development.NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation.
Precautions
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