Rabbit Polyclonal (IgG) to Human MYO7A/Myosin-VIIa; MYO7A; DFNA11; DFNB2; Myosin VIIA; MYOVIIA; MYU7A; USH1B; Unconventional myosin-VIIa; NSRD2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Recognizes endogenous levels of MYO7A protein.

Immunoaffinity Purified

PBS, pH 7.3, 0.01% sodium azide, 30% glycerol.

Store at -20 degree C.
Aliquot to avoid freeze/thaw cycles.

Small volumes of anti-MYO7A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. their highlydivergent tails bind to membranous compartments, which are then movedrelative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P: 1:100
WB: 1:500-1:1000

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

Western blot analysis of MYO7A expression in SKOVCAR (A); HEK293T (B) whole cell lysates.

249,165 Da

myosin VIIA

unconventional myosin-VIIa

Unconventional myosin-VIIa

USH1B??[Similar Products]

This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.

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