Anti-NLRP7 / NALP7 Antibody (N-Terminus) IHC-plus; NLRP7; CLR19.4; NALP7; NOD12; PYPAF3; PAN7; HYDM; Human NLRP7; NALP7

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human NLRP7

Immunoaffinity Purified

PBS, 0.02% sodium azide

1 mg/ml (lot specific)

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Small volumes of anti-NLRP7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: NALP7 antibody can be used for detection of NALP7 by Western blot at 1-2 ug/ml.

Anti-NLRP7 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Immunofluorescence of NALP7 in human brain tissue with NALP7 antibody at 20 ug/ml.

Western blot analysis of NALP7 in human brain tissue lysate with NALP7 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

118,303 Da

NLR family, pyrin domain containing 7

NACHT, LRR and PYD domains-containing protein 7; PYRIN-containing Apaf1-like protein 3; NACHT, LRR and PYD containing protein 7; NACHT, leucine rich repeat and PYD containing 7; nucleotide-binding oligomerization domain protein 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7

NACHT, LRR and PYD domains-containing protein 7

NALP7; NOD12; PYPAF3??[Similar Products]

NALP7_HUMAN

This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

NLRP7: Inhibits CASP1/caspase-1-dependent IL1B secretion. Defects in NLRP7 are the cause of hydatidiform mole recurrent type 1 (HYDM1). A disorder characterized by excessive trophoblast development and the presence of a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 19q13.42

Molecular Function: ATP binding

Disease: Hydatidiform Mole, Recurrent, 1

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