Full Product Name
COX42 Antibody
Product Synonym Names
Cytochrome c oxidase subunit 4 isoform 2,mitochondrial [Precursor]; EC 1.9.3.1; Cytochrome c oxidase subunit IV isoform 2; COX IV-2; COX4L2; COX42
Product Gene Name
anti-COX42 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96KJ9
Species Reactivity
Human, Mouse, Rat
Specificity
COX42 antibody detects endogenous levels of total COX42 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human COX42.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-COX42 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-COX42 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-COX42 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-COX42 antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:10000
Testing Data of anti-COX42 antibody
Western Blot (WB) of anti-COX42 antibody
Peptide-+ Western blot analysis of extracts from K562 cells, treated with insulin (0.01U/ml, 15mins), using COX42 antibody. Immunofluorescence analysis of COS7 cells, using COX42 antibody.
NCBI/Uniprot data below describe general gene information for COX42. It may not necessarily be applicable to this product.
NCBI Accession #
NP_115998.2
[Other Products]
NCBI GenBank Nucleotide #
NM_032609.2
[Other Products]
UniProt Primary Accession #
Q96KJ9
[Other Products]
UniProt Secondary Accession #
Q6GTF4; Q9H0Z4[Other Products]
UniProt Related Accession #
Q96KJ9[Other Products]
Molecular Weight
20,010 Da
NCBI Official Full Name
cytochrome c oxidase subunit 4 isoform 2, mitochondrial
NCBI Official Synonym Full Names
cytochrome c oxidase subunit 4I2
NCBI Official Symbol
COX4I2??[Similar Products]
NCBI Official Synonym Symbols
COX4; COX4B; COX4-2; COX4L2; COXIV-2; dJ857M17.2
??[Similar Products]
NCBI Protein Information
cytochrome c oxidase subunit 4 isoform 2, mitochondrial
UniProt Protein Name
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
UniProt Synonym Protein Names
Cytochrome c oxidase subunit IV isoform 2; COX IV-2
UniProt Gene Name
COX4I2??[Similar Products]
UniProt Synonym Gene Names
COX4L2; COX IV-2??[Similar Products]
NCBI Summary for COX42
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008]
UniProt Comments for COX42
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Product References and Citations for anti-COX42 antibody
Huettemann M., Gene 267:111-123(2001). Deloukas P., Nature 414:865-871(2001). The MGC Project Team, Genome Res. 14:2121-2127(2004).
Research Articles on COX42
1. Identification of three transcription factors that bind a conserved responsive element of the COX4I2 gene, namely recombination signal sequence-binding protein Jkappa (RBPJ), coiled-coil-helix-coiled-coil-helix domain 2 (CHCHD2) and CXXC finger protein 5 (CXXC5).
Precautions
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Disclaimer
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