Anti-COX4I2 Antibody (aa31-80) IHC-plus; COX4I2; COX4-2; COX4B; COX4; COX4L2; COX IV-2; COXIV-2; DJ857M17.2; Human COX4I2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

COX42 Antibody detects endogenous levels of total COX42 protein.

Immunoaffinity Purified

PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol

1 mg/ml (lot specific)

Store at -20 degree C for up to one year.

Small volumes of anti-COX4I2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

ELISA (1:10000), IF (1:100 - 1:500), IHC-P (20 ug/ml), WB (1:500 - 1:1000)

Anti-COX4I2 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

Immunofluorescence of COS7 cells, using COX42 Antibody. The picture on the right is treated with the synthesized peptide.

Western blot of extracts from K562 cells, treated with insulin 0.01U/ml 15', using COX42 Antibody. The lane on the right is treated with the synthesized peptide.

20,010 Da

cytochrome c oxidase subunit IV isoform 2 (lung)

cytochrome c oxidase subunit 4 isoform 2, mitochondrial; COX IV-2; cytochrome c oxidase subunit IV-like 2

Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

COX4L2; COX IV-2??[Similar Products]

COX42_HUMAN

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008]

COX4I2: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Defects in COX4I2 are the cause of exocrine pancreatic insufficiency dyserythropoietic anemia and calvarial hyperostosis (EPIDACH). Patients present with pancreatic insufficiency, intestinal malabsorption, failure to thrive, and anemia soon after birth. Belongs to the cytochrome c oxidase IV family.

Protein type: Oxidoreductase; Mitochondrial

Chromosomal Location of Human Ortholog: 20q11.21

Cellular Component: mitochondrial respiratory chain complex IV

Molecular Function: cytochrome-c oxidase activity

Biological Process: generation of precursor metabolites and energy; cellular respiration

Disease: Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, And Calvarial Hyperostosis

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