Product Name
Aprataxin (APTX), Recombinant Protein
Full Product Name
Recombinant Ciona intestinalis Aprataxin (APTX)
Product Gene Name
APTX recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-380aa, full length protein
Sequence
MRILYRLLKM ADDTVKCYLE CCKSSHPKLP LPHNVPVIIG RTPELGITDK LCSRSQLELT SNCYKRYVLV KRLGANTSQI NGIDIEKNKS SRLEEGQDLH VVNGKFPHRV YFTGCQNDTK TEKAVVPKLP TKSTDLTKSD LSIKQPERKK LKVSENKSKV LNSKIKPQEK FSSESVYAFD SPSPMSSRCE KKAESNKRAP THKHWSQGLK ASMEDPELVV KEDEQIVVIK DKYPKAKYHW LILPKDSISS TKNLSTDNIE LLKHILKVGQ ELAAEVKDKQ PDVEFRFGYH AVASMSQMHM HVISQDFQSS SFKTKKHWNS FTTDYFVDAT DIINELETGG KVKDRRTMTS LLNEPLKCHR CKKPQKNIPT LKKHIDSCQK
3D Structure
ModBase 3D Structure for P61802
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of APTX recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for APTX. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001027704.1
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NCBI GenBank Nucleotide #
NM_001032532.1
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UniProt Primary Accession #
P61802
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UniProt Related Accession #
P61802[Other Products]
Molecular Weight
43,441 Da
NCBI Official Full Name
aprataxin
NCBI Official Symbol
aptx??[Similar Products]
NCBI Protein Information
aprataxin
UniProt Protein Name
Aprataxin
UniProt Synonym Protein Names
Forkhead-associated domain histidine triad-like protein; FHA-HIT
UniProt Gene Name
APTX??[Similar Products]
UniProt Synonym Gene Names
FHA-HIT??[Similar Products]
UniProt Comments for APTX
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
