Product Name
Aprataxin (APTX), Recombinant Protein
Full Product Name
Recombinant Bovine Aprataxin (APTX)
Product Gene Name
APTX recombinant protein
[Similar Products]
Product Synonym Gene Name
APTX[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-356aa, full length protein
Sequence
MSNVSLSASA VSRVMMRVCW LVRQDNRHQR IKLPHLETVM VGRSPETKIA DKKCSRQQVQ LKAECNKGYV KVKQVGVNPT SIDSVIIGKD QEVKLQPGQV LYLVNELYPY IIEFEEETKS PGLESHRKRK RSGSSDPTER GADPEAEPST GLEPGSNPHQ CSVPPKKEKD ASIKKESLGH WSQGLKISME DPKMQVYKDE QVVVIKDKYP KARFHWLVLP WASISSLKAV TREHLELLRH MHAVGEKVIA DFAGSSKFRF RLGYHAIPSM SHVHLHVISQ DFDSPCLKNK KHWNSFNTEY FLESQAVIEM VQEAGRVTVR DGMPELLKLP LRCHECQQLL PSIPQLKEHL RKHWSK
3D Structure
ModBase 3D Structure for Q7YRZ2
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of APTX recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
APTX recombinant protein
This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.
NCBI/Uniprot data below describe general gene information for APTX. It may not necessarily be applicable to this product.
NCBI Accession #
NP_872595.1
[Other Products]
NCBI GenBank Nucleotide #
NM_182654.1
[Other Products]
UniProt Primary Accession #
Q7YRZ2
[Other Products]
UniProt Related Accession #
Q7YRZ2[Other Products]
Molecular Weight
40,659 Da
NCBI Official Full Name
aprataxin
NCBI Official Synonym Full Names
aprataxin
NCBI Official Symbol
APTX??[Similar Products]
NCBI Protein Information
aprataxin
UniProt Protein Name
Aprataxin
UniProt Synonym Protein Names
Forkhead-associated domain histidine triad-like protein; FHA-HIT
UniProt Gene Name
APTX??[Similar Products]
UniProt Synonym Gene Names
FHA-HIT??[Similar Products]
UniProt Comments for APTX
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
