DNT; DNT1; P5N2; PN-I; PN-II; UMPH2; cdN; 5'Nucleotidase,Deoxy(Pyrimidine)Cytosolic Type C; Uridine 5-Prime Monophosphate Hydrolase 2; 5'(3')-deoxyribonucleotidase, cytosolic

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

200ug/ml (lot specific)

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.

Small volumes of anti-NT5C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunohistochemistry (IHC)

13,299 Da

5', 3'-nucleotidase, cytosolic

5'(3')-deoxyribonucleotidase, cytosolic type

5'(3')-deoxyribonucleotidase, cytosolic type

DNT1; UMPH2; dNT-1??[Similar Products]

This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

NT5C: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. Belongs to the 5'(3')-deoxyribonucleotidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 3.1.3.-; Hydrolase; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleus

Molecular Function: 5'-nucleotidase activity; metal ion binding; nucleotidase activity; pyrimidine nucleotide binding

Biological Process: dephosphorylation; purine nucleotide catabolic process; pyrimidine deoxyribonucleotide catabolic process; pyrimidine nucleoside catabolic process

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