Product Name
COXIV Isoform 2 (COX4I2), Blocking Peptide
Full Product Name
COXIV Isoform 2 Blocking Peptide
Product Synonym Names
Cytochrome c oxidase subunit 4 isoform 2; mitochondrial; Cytochrome c oxidase subunit IV isoform 2; COX IV-2; COX4I2; COX4L2
Product Gene Name
COX4I2 blocking peptide
[Similar Products]
Product Synonym Gene Name
COX4L2[Similar Products]
COXIV Isoform 2 peptide (MBS9230725) is used for blocking the activity of COXIV antibody (MBS9217290)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96KJ9
Specificity
The synthetic peptide sequence is selected from aa 161-171 of HUMAN COX4I2
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Mitochondrion inner membrane.
Tissue Location
Highly expressed in lung.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of COX4I2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
COX4I2 blocking peptide
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
NCBI/Uniprot data below describe general gene information for COX4I2. It may not necessarily be applicable to this product.
NCBI Accession #
Q96KJ9.2
[Other Products]
UniProt Primary Accession #
Q96KJ9
[Other Products]
UniProt Secondary Accession #
Q6GTF4; Q9H0Z4[Other Products]
UniProt Related Accession #
Q96KJ9[Other Products]
Molecular Weight
20,010 Da
NCBI Official Full Name
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
NCBI Official Synonym Full Names
cytochrome c oxidase subunit 4I2
NCBI Official Symbol
COX4I2??[Similar Products]
NCBI Official Synonym Symbols
COX4; COX4B; COX4-2; COX4L2; COXIV-2; dJ857M17.2
??[Similar Products]
NCBI Protein Information
cytochrome c oxidase subunit 4 isoform 2, mitochondrial
UniProt Protein Name
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
UniProt Synonym Protein Names
Cytochrome c oxidase subunit IV isoform 2; COX IV-2
UniProt Gene Name
COX4I2??[Similar Products]
UniProt Synonym Gene Names
COX4L2; COX IV-2??[Similar Products]
UniProt Entry Name
COX42_HUMAN
NCBI Summary for COX4I2
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008]
UniProt Comments for COX4I2
COX4I2: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Defects in COX4I2 are the cause of exocrine pancreatic insufficiency dyserythropoietic anemia and calvarial hyperostosis (EPIDACH). Patients present with pancreatic insufficiency, intestinal malabsorption, failure to thrive, and anemia soon after birth. Belongs to the cytochrome c oxidase IV family.
Protein type: Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 20q11.21
Cellular Component: mitochondrial respiratory chain complex IV
Molecular Function: cytochrome-c oxidase activity
Biological Process: mitochondrial electron transport, cytochrome c to oxygen
Disease: Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, And Calvarial Hyperostosis
Research Articles on COX4I2
1. Identification of three transcription factors that bind a conserved responsive element of the COX4I2 gene, namely recombination signal sequence-binding protein Jkappa (RBPJ), coiled-coil-helix-coiled-coil-helix domain 2 (CHCHD2) and CXXC finger protein 5 (CXXC5).
Precautions
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Disclaimer
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