Product Name
IL9R, Blocking Peptide
Full Product Name
IL9R Peptide - middle region
Product Gene Name
IL9R blocking peptide
[Similar Products]
Product Synonym Gene Name
CD129; IL-9R[Similar Products]
IL9R peptide (MBS3246669) is used for blocking the activity of IL9R antibody (MBS3221952)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Synthetic peptide located within the following region: LPAGCTEWRV QTLAYLPQED WAPTSLTRPA PPDSEGSRSS SSSSSSNNNN
3D Structure
ModBase 3D Structure for Q01113
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of IL9R blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IL9R blocking peptide
This is a synthetic peptide designed for use in combination with anti- IL9R Antibody, made
Target Description: The protein encoded by this gene is a cytokine receptor that specifically mediates the
biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene.
Product Categories/Family for IL9R blocking peptide
Peptide
NCBI/Uniprot data below describe general gene information for IL9R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002177.2
[Other Products]
NCBI GenBank Nucleotide #
NM_002186.2
[Other Products]
UniProt Primary Accession #
Q01113
[Other Products]
UniProt Related Accession #
Q01113[Other Products]
NCBI Official Full Name
interleukin-9 receptor isoform 1
NCBI Official Synonym Full Names
interleukin 9 receptor
NCBI Official Symbol
IL9R??[Similar Products]
NCBI Official Synonym Symbols
CD129; IL-9R
??[Similar Products]
NCBI Protein Information
interleukin-9 receptor
UniProt Protein Name
Interleukin-9 receptor
Protein Family
Interleukin-9 receptor
UniProt Gene Name
IL9R??[Similar Products]
UniProt Synonym Gene Names
IL-9 receptor; IL-9R??[Similar Products]
UniProt Entry Name
IL9R_HUMAN
NCBI Summary for IL9R
The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for IL9R
IL9R: This is a receptor for interleukin-9. Belongs to the type I cytokine receptor family. Type 4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: Xq28 and Yq12
Cellular Component: extracellular space; integral to plasma membrane
Molecular Function: interleukin-9 binding; interleukin-9 receptor activity
Biological Process: cell proliferation; signal transduction; positive regulation of cell growth
Research Articles on IL9R
1. Results show that silencing of the IL-9R gene alleviates the drug resistance of diffuse large B-cell lymphoma (DLBCL) cell lines that is induced by IL-9 suggesting that IL-9R is involved in chemotherapy drug resistance of DLBCL.
Precautions
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Disclaimer
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