Product Name
CYP21A2, Polyclonal Antibody
Full Product Name
CYP21A2 Polyclonal Antibody
Product Gene Name
anti-CYP21A2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P08686
Other Notes
Small volumes of anti-CYP21A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CYP21A2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000491.4
[Other Products]
NCBI GenBank Nucleotide #
NM_000500.8
[Other Products]
UniProt Primary Accession #
P08686
[Other Products]
UniProt Secondary Accession #
P04033; Q01204; Q08AG8; Q16749; Q16806; Q5ST44; Q96NU8; A2BHY6[Other Products]
UniProt Related Accession #
P08686[Other Products]
Molecular Weight
52,597 Da
NCBI Official Full Name
steroid 21-hydroxylase isoform a
NCBI Official Synonym Full Names
cytochrome P450 family 21 subfamily A member 2
NCBI Official Symbol
CYP21A2??[Similar Products]
NCBI Official Synonym Symbols
CAH1; CPS1; CA21H; CYP21; CYP21B; P450c21B
??[Similar Products]
NCBI Protein Information
steroid 21-hydroxylase
UniProt Protein Name
Steroid 21-hydroxylase
UniProt Synonym Protein Names
21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21; Cytochrome P450-C21B
UniProt Gene Name
CYP21A2??[Similar Products]
UniProt Synonym Gene Names
CYP21; CYP21B??[Similar Products]
NCBI Summary for CYP21A2
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP21A2
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids (PubMed:22014889).
Research Articles on CYP21A2
1. Mutation in the CYP21A2 gene is associated with nonclassical 21-hydroxylase deficiency and final height.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
