21-hydroxylase; 21-OHase; CA21H; CAH1; CP21A; CPS1; CYP21A2; CYP21B; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; cytochrome P450, family 21, subfamily A, polypeptide 2; cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2; Cytochrome P450-C21; Cytochrome P450-C21B; MGC150536; MGC150537; P450c21B; Steroid 21-hydroxylase; steroid 21-monooxygenase

For Research Use Only. Not for use in diagnostic procedures.

CYP21A2 antibody detects endogenous levels of total CYP21A2 protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-CYP21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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Western Blot (WB), ELISA (EIA)

WB: 1:500~1:3000
ELISA: 1:40000

52,597 Da

cytochrome P450 family 21 subfamily A member 2

steroid 21-hydroxylase

Steroid 21-hydroxylase

CYP21; CYP21B??[Similar Products]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids (PubMed:22014889).

Higashi Y., Proc. Natl. Acad. Sci. U.S.A. 83:2841-2845(1986). White P.C., Proc. Natl. Acad. Sci. U.S.A. 83:5111-5115(1986). Rodrigues N.R., EMBO J. 6:1653-1661(1987).

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