Product Name
Mediterranean Fever (MEFV), Polyclonal Antibody
Full Product Name
Mediterranean Fever (MEFV, Pyrin, Marenostrin, MEF)
Product Synonym Names
Anti -Mediterranean Fever (MEFV, Pyrin, Marenostrin, MEF)
Product Gene Name
anti-MEFV antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 16; NC_000016.9 (3292028..3306648, complement). Location: 16p13.3
3D Structure
ModBase 3D Structure for O15553
Specificity
Recognizes human MEFV.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide corresponding to aa268-284 of human MEFV (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-MEFV antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MEFV antibody
MEFV was identified as the gene that when mutated causes Mediterranean fever, a hereditary periodic fever syndrome. MEFV is expressed in granulocytes and myeloid bone marrow precursors.
Product Categories/Family for anti-MEFV antibody
Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-MEFV antibody
ELISA (EL/EIA), Immunohistochemistry (IHC)
Application Notes for anti-MEFV antibody
Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
NCBI/Uniprot data below describe general gene information for MEFV. It may not necessarily be applicable to this product.
NCBI Accession #
AAI01538.1
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UniProt Primary Accession #
O15553
[Other Products]
UniProt Secondary Accession #
Q3MJ84; Q96PN4; Q96PN5; D3DUC0; F5H0Q3[Other Products]
UniProt Related Accession #
O15553[Other Products]
Molecular Weight
86,444 Da[Similar Products]
NCBI Official Full Name
Mediterranean fever
NCBI Official Synonym Full Names
Mediterranean fever
NCBI Official Symbol
MEFV??[Similar Products]
NCBI Official Synonym Symbols
FMF; MEF; TRIM20
??[Similar Products]
NCBI Protein Information
pyrin; marenostrin
UniProt Protein Name
Pyrin
UniProt Synonym Protein Names
Marenostrin
UniProt Gene Name
MEFV??[Similar Products]
UniProt Synonym Gene Names
MEF??[Similar Products]
UniProt Entry Name
MEFV_HUMAN
NCBI Summary for MEFV
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for MEFV
pyrin: Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization. Defects in MEFV are the cause of familial Mediterranean fever autosomal recessive (ARFMF). ARFMF is an inherited disorder characterized by recurrent episodic fever, serosal inflammation and pain in the abdomen, chest or joints. ARFMF is frequently complicated by amyloidosis, which leads to renal failure and can be prophylactically treated with colchicine. ARFMF primarily affects ancestral ethnic groups living around the Mediterranean basin: North African Jews, Armenians, Arabs and Turks. The disease is also distributed in other populations including Greeks, Cypriots, Italians and Spanish, although at a lower prevalence. Defects in MEFV are the cause of familial Mediterranean fever autosomal dominant (ADFMF). ADFMF is characterized by periodic fever, serosal inflammation and pain in the abdomen, chest or joints as seen also in the autosomal recessive form of the disease. It is associated with renal amyloidosis and characterized by colchicine unresponsiveness. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: ruffle; microtubule; microtubule associated complex; lamellipodium; cytosol; nucleus
Molecular Function: zinc ion binding; actin binding
Biological Process: negative regulation of interleukin-12 production; negative regulation of inflammatory response; innate immune response; negative regulation of interleukin-1 beta production; inflammatory response
Disease: Familial Mediterranean Fever; Familial Mediterranean Fever, Autosomal Dominant
Research Articles on MEFV
1. FMF phenotype analysis is a good indicator for disease progression in patients diagnosed with familial mediterranean fever.
Precautions
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