Extracellular serine/threonine protein kinase FAM20C; Dentin matrix protein 4; DMP-4; Golgi-enriched fraction casein kinase; GEF-CK; Protein FAM20C; FAM20C; DMP4

For Research Use Only. Not for use in diagnostic procedures.

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Small volumes of FAM20C blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Calcium-binding kinase that phosphorylates the caseins and several secreted proteins implicated in biomineralization, including the secretory calcium binding phosphoproteins (SCPP). Preferencially phosphorylates its targets within the S-x-E/pS motif.

29,597 Da

family with sequence similarity 20 member C

extracellular serine/threonine protein kinase FAM20C

Extracellular serine/threonine protein kinase FAM20C

GEF-CK??[Similar Products]

FA20C_HUMAN

This gene encodes a member of the family of secreted protein kinases. The encoded protein binds calcium and phosphorylates proteins involved in bone mineralization. Mutations in this gene are associated with the autosomal recessive disorder Raine syndrome. [provided by RefSeq, Apr 2014]

FAM20C: an atypical serine protein kinase that localizes within the Golgi apparatus and is secreted. Distantly related to the Drosophila Golgi-localized kinase Four-jointed. Phosphorylates secretory proteins including the caseins and members of the small integrin-binding ligand, N-linked glycoprotein (SIBLING) protein family, which modulate biomineralization. Colocalizes with the Golgi resident protein GM130. Preferentially phosphorylates its targets within the S-x-E/pS motif. Requires Mn2+ as an alternative to Mg2+ as the activating cation. Defects in FAM20C are the cause of Raine syndrome (RNS). RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly. Two isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Secreted, signal peptide; Secreted; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 7p22.3

Cellular Component: extracellular space; Golgi apparatus

Molecular Function: manganese ion binding; protein binding; protein serine/threonine kinase activity

Biological Process: biomineral formation; protein amino acid phosphorylation

Disease: Raine Syndrome

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