Product Name
Extracellular serine/threonine protein kinase FAM20C (FAM20C), Recombinant Protein
Popular Item
Full Product Name
Recombinant Human Extracellular serine/threonine protein kinase FAM20C (FAM20C)
Product Gene Name
FAM20C recombinant protein
[Similar Products]
Product Synonym Gene Name
FAM20C[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
93-584aa; Full Length of Mature Protein
Sequence
DFSSDPSSNL SSHSLEKLPP AAEPAERALR GRDPGALRPH DPAHRPLLRD PGPRRSESPP GPGGDASLLA RLFEHPLYRV AVPPLTEEDV LFNVNSDTRL SPKAAENPDW PHAGAEGAEF LSPGEAAVDS YPNWLKFHIG INRYELYSRH NPAIEALLHD LSSQRITSVA MKSGGTQLKL IMTFQNYGQA LFKPMKQTRE QETPPDFFYF SDYERHNAEI AAFHLDRILD FRRVPPVAGR MVNMTKEIRD VTRDKKLWRT FFISPANNIC FYGECSYYCS TEHALCGKPD QIEGSLAAFL PDLSLAKRKT WRNPWRRSYH KRKKAEWEVD PDYCEEVKQT PPYDSSHRIL DVMDMTIFDF LMGNMDRHHY ETFEKFGNET FIIHLDNGRG FGKYSHDELS ILVPLQQCCR IRKSTYLRLQ LLAKEEYKLS LLMAESLRGD QVAPVLYQPH LEALDRRLRV VLKAVRDCVE RNGLHSVVDD DLDTEHRAAS AR
3D Structure
ModBase 3D Structure for Q8IXL6
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Storage Buffer
Tris-based buffer, 50% glycerol
Production Note
Special Offer: The Mammalian-Cell host-expressed protein is manufactured from a stock plasmid containing the protein gene. Mammalian-Cellhost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Mammalian-Cell host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Mammalian-Cell host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of FAM20C recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
SDS-Page of FAM20C recombinant protein
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for FAM20C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_064608.2
[Other Products]
NCBI GenBank Nucleotide #
NM_020223.3
[Other Products]
UniProt Primary Accession #
Q8IXL6
[Other Products]
UniProt Secondary Accession #
Q5I0W9; Q7Z4I0; Q9NPT2; A4D2Q5; L8B5W8[Other Products]
UniProt Related Accession #
Q8IXL6[Other Products]
Molecular Weight
29,597 Da
NCBI Official Full Name
extracellular serine/threonine protein kinase FAM20C
NCBI Official Synonym Full Names
FAM20C, golgi associated secretory pathway kinase
NCBI Official Symbol
FAM20C??[Similar Products]
NCBI Official Synonym Symbols
RNS; DMP4; G-CK; DMP-4; GEF-CK
??[Similar Products]
NCBI Protein Information
extracellular serine/threonine protein kinase FAM20C
UniProt Protein Name
Extracellular serine/threonine protein kinase FAM20C
UniProt Synonym Protein Names
Dentin matrix protein 4
Protein Family
Extracellular serine/threonine protein kinase
UniProt Gene Name
FAM20C??[Similar Products]
UniProt Synonym Gene Names
GEF-CK??[Similar Products]
NCBI Summary for FAM20C
This gene encodes a member of the family of secreted protein kinases. The encoded protein binds calcium and phosphorylates proteins involved in bone mineralization. Mutations in this gene are associated with the autosomal recessive disorder Raine syndrome. [provided by RefSeq, Apr 2014]
UniProt Comments for FAM20C
Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039).
Research Articles on FAM20C
1. findings clarify FAM20C's role in hard tissue formation and mineralization, and show that Raine syndrome is congenital sclerosing osteomalacia with cerebral calcification.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
