Anti-Pyrin / MEFV / MEF Antibody (aa268-284) IHC-plus; MEFV; Mediterranean fever; MEF; Pyrin; TRIM20; FMF; Marenostrin; Human Pyrin; MEFV; MEF

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Amino acids 268 to 284 of human MEFV

Protein G Purified

PBS, 0.09% sodium azide.

1 mg/ml (lot specific)

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Small volumes of anti-MEF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

ELISA (1:000 - 1:1000), IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Anti-MEFV antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Anti-MEFV antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

50,837 Da

Mediterranean fever

pyrin; marenostrin

Pyrin

MEF??[Similar Products]

MEFV_HUMAN

This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008]

pyrin: Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization. Defects in MEFV are the cause of familial Mediterranean fever autosomal recessive (ARFMF). ARFMF is an inherited disorder characterized by recurrent episodic fever, serosal inflammation and pain in the abdomen, chest or joints. ARFMF is frequently complicated by amyloidosis, which leads to renal failure and can be prophylactically treated with colchicine. ARFMF primarily affects ancestral ethnic groups living around the Mediterranean basin: North African Jews, Armenians, Arabs and Turks. The disease is also distributed in other populations including Greeks, Cypriots, Italians and Spanish, although at a lower prevalence. Defects in MEFV are the cause of familial Mediterranean fever autosomal dominant (ADFMF). ADFMF is characterized by periodic fever, serosal inflammation and pain in the abdomen, chest or joints as seen also in the autosomal recessive form of the disease. It is associated with renal amyloidosis and characterized by colchicine unresponsiveness. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: ruffle; microtubule; microtubule associated complex; lamellipodium; cytosol; nucleus

Molecular Function: zinc ion binding; actin binding

Biological Process: negative regulation of interleukin-12 production; negative regulation of inflammatory response; innate immune response; negative regulation of interleukin-1 beta production; inflammatory response

Disease: Familial Mediterranean Fever; Familial Mediterranean Fever, Autosomal Dominant

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