Rabbit Polyclonal (IgG) to Human FAM20C; FAM20C; Dentin matrix protein 4; DMP4; GEF-CK; IMAGE:4942737; Protein FAM20C; RNS; DMP-4

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

This DMP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-471 amino acids from the C-terminal region of human DMP4.

Protein A purified

PBS, 0.09% sodium azide

Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.

Small volumes of anti-FAM20C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Calcium-binding kinase that phosphorylates the caseins and several secreted proteins implicated in biomineralization, including the secretory calcium binding phosphoproteins (SCPP). Preferencially phosphorylates its targets within the S-x-E/pS motif.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P: 1:50-1:100
WB: 1:1000

DMP4 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human breast carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)

DMP4 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The DMP4 antibody detected the DMP4 protein (arrow).

29,597 Da

FAM20C, golgi associated secretory pathway kinase

extracellular serine/threonine protein kinase FAM20C

Extracellular serine/threonine protein kinase FAM20C

GEF-CK??[Similar Products]

This gene encodes a member of the family of secreted protein kinases. The encoded protein binds calcium and phosphorylates proteins involved in bone mineralization. Mutations in this gene are associated with the autosomal recessive disorder Raine syndrome. [provided by RefSeq, Apr 2014]

Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039).

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