DMP4

For Research Use Only. Not for use in diagnostic procedures.

Baculovirus-Insect Cells

> 85 % as determined by SDS-PAGE.

Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol

Samples are stable for up to twelve months from date of receipt at -70 degree C

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of FAM20C / DMP4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

A DNA sequence encoding the human FAM20C (NP_064608.2) (Met1-Arg584) was expressed with a polyhistidine tag at the C-terminus.

The recombinant human FAM20C consists 573 amino acids and predicts a molecular mass of 65.1 kDa.

29,597 Da

FAM20C, golgi associated secretory pathway kinase

extracellular serine/threonine protein kinase FAM20C

Extracellular serine/threonine protein kinase FAM20C

GEF-CK??[Similar Products]

This gene encodes a member of the family of secreted protein kinases. The encoded protein binds calcium and phosphorylates proteins involved in bone mineralization. Mutations in this gene are associated with the autosomal recessive disorder Raine syndrome. [provided by RefSeq, Apr 2014]

FAM20C: an atypical serine protein kinase that localizes within the Golgi apparatus and is secreted. Distantly related to the Drosophila Golgi-localized kinase Four-jointed. Phosphorylates secretory proteins including the caseins and members of the small integrin-binding ligand, N-linked glycoprotein (SIBLING) protein family, which modulate biomineralization. Colocalizes with the Golgi resident protein GM130. Preferentially phosphorylates its targets within the S-x-E/pS motif. Requires Mn2+ as an alternative to Mg2+ as the activating cation. Defects in FAM20C are the cause of Raine syndrome (RNS). RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly. Two isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p22.3

Cellular Component: extracellular space; Golgi apparatus

Molecular Function: manganese ion binding; protein binding; protein serine/threonine kinase activity

Biological Process: biomineral formation; protein amino acid phosphorylation

Disease: Raine Syndrome

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