Anti -FTCD/Golgi protein, internal (LCHC1, Formiminotransferase Cyclodeaminase, Formimidoyltransferase Cyclodeaminase)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 21; NC_000021.8 (47556176..47575481, complement). Location: 21q22.3

Polyclonal

IgG

Goat

Recognizes human FTCD. Species sequence homology: Mouse. This antibody is expected to recognize both reported isoforms.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02%sodium azide.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-FTCD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Golgi Proteins

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:32,000
Western Blot: 0.03-0.1ug/ml. A 55-60kD band observed in Human Liver lysates (calculated MW of 58.9kD according to NP_006648 and NP_996848). A 55-60kD band observed in Human Liver lysates

58,927 Da[Similar Products]

formiminotransferase cyclodeaminase

formimidoyltransferase-cyclodeaminase; OTTHUMP00000115563; OTTHUMP00000115564; OTTHUMP00000115565; OTTHUMP00000115566; formiminotransferase-cyclodeaminase; formimidoyltransferase cyclodeaminase

Formimidoyltransferase-cyclodeaminase

FTCD??[Similar Products]

FTCD_HUMAN

The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.

FTCD: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency (FIGLU-URIA); also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; EC 4.3.1.4; Amino Acid Metabolism - histidine; Lyase; EC 2.1.2.5; Cofactor and Vitamin Metabolism - one carbon pool by folate

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: centriole; Golgi apparatus; cytoplasm; cytosol

Molecular Function: formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; folic acid binding

Biological Process: folic acid and derivative metabolic process; cytoskeleton organization and biogenesis; histidine catabolic process to glutamate and formamide; histidine catabolic process; histidine catabolic process to glutamate and formate

Disease: Formiminotransferase Deficiency

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