bA100C15.2; EIEE14; ENFL5; KCa4.1; KCNT1; KCNT1_HUMAN; Potassium channel subfamily T member 1; Potassium channel, sodium activated subfamily T, member 1; Potassium channel, subfamily T, member 1; Sequence like a calcium-activated K+ channel; SLACK; Slo2.2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

KCNT1 antibody detects endogenous levels of total KCNT1

The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.

Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1mg/ml (lot specific)

Store at -20 degree C. Stable for 12 months from date of receipt.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Small volumes of anti-KCNT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Function: Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity).
Subunit Structure: Interacts (via C-terminus) with FMR1; this interaction alters gating properties of KCNT1 (PubMed:20512134). Interacts with CRBN via its cytoplasmic C-terminus (By similarity).
Post-translational Modifications: Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity (By similarity).
Similarity: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily.

Western Blot (WB), ELISA (EIA)

WB: 1:1000

Western blot analysis of KCNT1 using K562 whole cell lysates

Observed: 140 kDa
Predicted: 139 kDa

potassium sodium-activated channel subfamily T member 1

potassium channel subfamily T member 1

Potassium channel subfamily T member 1

KIAA1422??[Similar Products]

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) ().

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