Full Product Name
KCNT1 Antibody
Product Synonym Names
Potassium channel subfamily T member 1; KCa4.1
Product Gene Name
anti-KCNT1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q5JUK3
Specificity
The antibody detects endogenous levels of total KCNT1 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from C-terminal of human KCNT1.
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-KCNT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KCNT1 antibody
Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) By similarity.Humphray S.J.,Nature 429:369-374(2004).Nagase T.,DNA Res. 7:65-73(2000).
Product Categories/Family for anti-KCNT1 antibody
Total protein Ab
Applications Tested/Suitable for anti-KCNT1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-KCNT1 antibody
Immunohistochemistry: 1:50~1:100
Immunohistochemistry (IHC) of anti-KCNT1 antibody
Immunohistochemistry analysis of paraffin-embedded human brain tissue using KCNT1 antibody.
NCBI/Uniprot data below describe general gene information for KCNT1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001258932.1
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NCBI GenBank Nucleotide #
NM_001272003.1
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UniProt Primary Accession #
Q5JUK3
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UniProt Secondary Accession #
Q9P2C5; B3KXF7; B7ZVY4; B9EGP2; G5E9V0[Other Products]
UniProt Related Accession #
Q5JUK3[Other Products]
Molecular Weight
136,987 Da
NCBI Official Full Name
potassium channel subfamily T member 1 isoform 2
NCBI Official Synonym Full Names
potassium channel, sodium activated subfamily T, member 1
NCBI Official Symbol
KCNT1??[Similar Products]
NCBI Official Synonym Symbols
ENFL5; SLACK; EIEE14; KCa4.1; Slo2.2; bA100C15.2
??[Similar Products]
NCBI Protein Information
potassium channel subfamily T member 1
UniProt Protein Name
Potassium channel subfamily T member 1
UniProt Synonym Protein Names
KCa4.1
Protein Family
Potassium channel subfamily
UniProt Gene Name
KCNT1??[Similar Products]
UniProt Synonym Gene Names
KIAA1422??[Similar Products]
UniProt Entry Name
KCNT1_HUMAN
NCBI Summary for KCNT1
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
UniProt Comments for KCNT1
KCNT1: Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro). Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: voltage-gated potassium channel complex
Molecular Function: calcium-activated potassium channel activity; voltage-gated potassium channel activity
Disease: Epilepsy, Nocturnal Frontal Lobe, 5; Epileptic Encephalopathy, Early Infantile, 14
Research Articles on KCNT1
1. Nine different mutations of the KCNT1 (Slack) Na(+)-activated K(+) channel give rise to three distinct forms of epilepsy.
Precautions
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Disclaimer
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