Full Product Name
KCNT1 Antibody
Product Synonym Names
FLJ41282; KCa4.1; SLACK; bA100C15.2
Product Gene Name
anti-KCNT1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Antigen affinity purification
Immunogen
Peptide of KCNT1
Calculated Molecular Weight: 138kd
Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-KCNT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KCNT1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for KCNT1. It may not necessarily be applicable to this product.
NCBI Accession #
AAI36619.1
[Other Products]
UniProt Secondary Accession #
Q9P2C5; B3KXF7; B7ZVY4; B9EGP2; G5E9V0[Other Products]
UniProt Related Accession #
Q5JUK3[Other Products]
Molecular Weight
136,987 Da
NCBI Official Full Name
KCNT1 protein
NCBI Official Synonym Full Names
potassium channel, sodium activated subfamily T, member 1
NCBI Official Symbol
KCNT1??[Similar Products]
NCBI Official Synonym Symbols
ENFL5; SLACK; EIEE14; KCa4.1; Slo2.2; bA100C15.2
??[Similar Products]
NCBI Protein Information
potassium channel subfamily T member 1; Sequence like a calcium-activated K+ channel; potassium channel, subfamily T, member 1
UniProt Protein Name
Potassium channel subfamily T member 1
UniProt Synonym Protein Names
KCa4.1
Protein Family
Potassium channel subfamily
UniProt Gene Name
KCNT1??[Similar Products]
UniProt Synonym Gene Names
KIAA1422??[Similar Products]
UniProt Entry Name
KCNT1_HUMAN
NCBI Summary for KCNT1
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
UniProt Comments for KCNT1
KCNT1: Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro). Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: voltage-gated potassium channel complex
Molecular Function: voltage-gated potassium channel activity; calcium-activated potassium channel activity
Disease: Epilepsy, Nocturnal Frontal Lobe, 5; Epileptic Encephalopathy, Early Infantile, 14
Research Articles on KCNT1
1. Genetic studies reveal two novel genes for Ohtahara Syndrome: KCNT1 and PIGQ.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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